Asset Details
Do you wish to reserve the book?
Two waves of evolution in the rodent pregnancy-specific glycoprotein (Psg) gene family lead to structurally diverse PSGs
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Two waves of evolution in the rodent pregnancy-specific glycoprotein (Psg) gene family lead to structurally diverse PSGs
Do you wish to request the book?
Two waves of evolution in the rodent pregnancy-specific glycoprotein (Psg) gene family lead to structurally diverse PSGs
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Two waves of evolution in the rodent pregnancy-specific glycoprotein (Psg) gene family lead to structurally diverse PSGs
2023
Overview
Background
The evolution of pregnancy-specific glycoprotein (PSG) genes within the CEA gene family of primates correlates with the evolution of hemochorial placentation about 45 Myr ago. Thus, we hypothesized that hemochorial placentation with intimate contact between fetal cells and maternal immune cells favors the evolution and expansion of PSGs. With only a few exceptions, all rodents have hemochorial placentas thus the question arises whether
Psgs
evolved in all rodent genera.
Results
In the analysis of 94 rodent species from 4 suborders, we identified
Psg
genes only in the suborder Myomorpha in three families (characteristic species in brackets), namely Muridae (mouse), Cricetidae (hamster) and Nesomyidae (giant pouched rat). All
Psgs
are located, as previously described for mouse and rat, in a region of the genome separated from the
Cea
gene family locus by several megabases, further referred to as the rodent
Psg
locus. In the suborders Castorimorpha (beaver), Hystricognatha (guinea pig) and Sciuromorpha (squirrel), neither
Psg
genes nor so called CEA-related cell adhesion molecule (
Ceacam
) genes were found in the
Psg
locus. There was even no evidence for the existence of
Psgs
in any other genomic region. In contrast to the
Psg
-harboring rodent species, which do not have activating CEACAMs, we were able to identify
Ceacam
genes encoding activating CEACAMs in all other rodents studied. In the
Psg
locus, there are genes encoding three structurally distinct CEACAM/PSGs: (i) CEACAMs composed of one N- and one A2-type domain (CEACAM9, CEACAM15), (ii) composed of two N domains (CEACAM11-CEACAM14) and (iii) composed of three to eight N domains and one A2 domain (PSGs). All of them were found to be secreted glycoproteins preferentially expressed by trophoblast cells, thus they should be considered as PSGs.
Conclusion
In rodents
Psg
genes evolved only recently in the suborder Myomorpha shortly upon their most recent common ancestor (MRCA) has coopted the retroviral genes syncytin-A and syncytin-B which enabled the evolution of the three-layered trophoblast. The expansion of
Psgs
is limited to the
Psg
locus most likely after a translocation of a CEA-related gene – possibly encoding an ITAM harboring CEACAM. According to the expression pattern two waves of gene amplification occurred, coding for structurally different PSGs.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Animal Genetics and Genomics
/ Biomedical and Life Sciences
/ carcinoembryonic antigen (CEA)
/ Carcinoembryonic antigen-related cell–cell adhesion molecule (CEACAM)
/ Fetuses
/ Genes
/ Genomes
/ Genomics
/ Mice
/ Microbial Genetics and Genomics
/ Placenta
/ Pregnancy-specific glycoprotein (PSG)
/ Rodents
/ Syncytin
