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Comparative Genomics of Transcriptional Regulation of Methionine Metabolism in Proteobacteria
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Comparative Genomics of Transcriptional Regulation of Methionine Metabolism in Proteobacteria
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Comparative Genomics of Transcriptional Regulation of Methionine Metabolism in Proteobacteria
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Journal Article
Comparative Genomics of Transcriptional Regulation of Methionine Metabolism in Proteobacteria
2014
Overview
Methionine metabolism and uptake genes in Proteobacteria are controlled by a variety of RNA and DNA regulatory systems. We have applied comparative genomics to reconstruct regulons for three known transcription factors, MetJ, MetR, and SahR, and three known riboswitch motifs, SAH, SAM-SAH, and SAM_alpha, in ∼ 200 genomes from 22 taxonomic groups of Proteobacteria. We also identified two novel regulons: a SahR-like transcription factor SamR controlling various methionine biosynthesis genes in the Xanthomonadales group, and a potential RNA regulatory element with terminator-antiterminator mechanism controlling the metX or metZ genes in beta-proteobacteria. For each analyzed regulator we identified the core, taxon-specific and genome-specific regulon members. By analyzing the distribution of these regulators in bacterial genomes and by comparing their regulon contents we elucidated possible evolutionary scenarios for the regulation of the methionine metabolism genes in Proteobacteria.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Analysis
/ Bacteria
/ Bacterial Proteins - metabolism
/ Comparative Genomic Hybridization
/ DNA
/ E coli
/ Enzymes
/ Gene Expression Regulation, Bacterial
/ Genes
/ Genomes
/ Genomics
/ Kinases
/ Proteins
/ Regulatory Elements, Transcriptional
/ regulons
/ RNA
/ Sulfur
/ Taxonomy
/ Transcription Factors - metabolism
/ Vibrio
