Journal Article

Oxidative Stress Predicts All-Cause Mortality in HIV-Infected Patients

Oteo, Jose A., Padilla, Sergio, Fernández, Marta, Moreno, Santiago, Antela, Antonio, del Amo, Julia, Masiá, Mar, Rodríguez, Carmen, Moreno, Ana, Gutiérrez, Félix

2016

Overview

We aimed to assess whether oxidative stress is a predictor of mortality in HIV-infected patients. We conducted a nested case-control study in CoRIS, a contemporary, multicentre cohort of HIV-infected patients, antiretroviral-naïve at entry, launched in 2004. Cases were patients who died with available stored plasma samples collected. Two age and sex-matched controls for each case were selected. We measured F2-isoprostanes (F2-IsoPs) and malondialdehyde (MDA) plasma levels in the first blood sample obtained after cohort engagement. 54 cases and 93 controls were included. Median F2-IsoPs and MDA levels were significantly higher in cases than in controls. When adjustment was performed for age, HIV-transmission category, CD4 cell count and HIV viral load at cohort entry, and subclinical inflammation measured with highly-sensitive C-reactive protein (hsCRP), the association of F2-IsoPs with mortality remained significant (adjusted OR per 1 log10 increase, 2.34 [1.23-4.47], P = 0.009). The association of MDA with mortality was attenuated after adjustment: adjusted OR (95% CI) per 1 log10 increase, 2.05 [0.91-4.59], P = 0.080. Median hsCRP was also higher in cases, and it also proved to be an independent predictor of mortality in the adjusted analysis: OR (95% CI) per 1 log10 increase, 1.39 (1.01-1.91), P = 0.043; and OR (95% CI) per 1 log10 increase, 1.46 (1.07-1.99), P = 0.014, respectively, when adjustment included F2-IsoPs and MDA. Oxidative stress is a predictor of all-cause mortality in HIV-infected patients. For plasma F2-IsoPs, this association is independent of HIV-related factors and subclinical inflammation.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Acquired immune deficiency syndrome / Adult / AIDS / Antiretroviral agents / Antiretroviral drugs / Biology and Life Sciences / C-reactive protein / Case-Control Studies / Cause of Death / CD4 antigen / Chemical compounds / Disease transmission / F2-Isoprostanes - blood / Female / Health aspects / Health risk assessment / HIV / HIV Infections - metabolism / HIV Infections - mortality / HIV patients / Human immunodeficiency virus / Humans / Isoprostanes / Male / Malondialdehyde / Malondialdehyde - blood / Medicine and Health Sciences / Middle Aged / Mortality / Oxidative Stress / Patient outcomes / Patients / Plasma levels / Sexually transmitted diseases / STD