Journal Article

Astragalus Membranaceus Improving Asymptomatic Left Ventricular Diastolic Dysfunction in Postmenopausal Hypertensive Women with Metabolic Syndrome： A Prospective, Open-Labeled, Randomized Controlled Trial

Ning-Yin Li;Heng Yu;Xiu-Li Li;Qiong-Ying Wang;Xiao-Wei Zhang;Rui-Xin Ma;Yang Zhao;Han Xu;Wei Liang;Feng Bai;Jing Yu

2018

Overview

Background： Postmenopausal women with metabolic syndrome （MetS） have increased cardiovascular morbidity and left ventricular diastolic dysfunction （LVDD）. The various protective effects ofastragalus membranaceus （AM） have been described in previous studies. Therefore, this study aimed to evaluate the effects of different doses of AM on diastolic function in postmenopausal hypertensive women with MetS. Methods： This was a prospective, randomized controlled study. The postmenopausal hypertensive patients with MetS were enrolled from Lanzhou University Second Hospital from March 2014 to April 2015. Patients were divided into three groups： control group （received conventional medical treatment）, AM Group 1 （received AM capsules at 5 g/d additionally）, and AM Group 2 （received AM capsules at 10 g/d additionally）. Echocardiographic and clinical characteristics were evaluated before and 12 months after treatment. Quantitative data were analyzed using unpaired t-test, analysis of variance, and multiple linear regression analysis. Results： A total of 154 patients were subjected to final analysis. In the AM Group 2, significant improvements were noted in diastolic function 12 months after treatment than those of the control group, including the early diastolic mitral annular velocity （E＇; 0.065±0.007 m/s vs. 0.061 ± 0.008 m/s, P = 0.014）, the ratio of the early diastolic mitral peak flow velocity to the late diastolic mitral peak flow velocity （E/A; 0.81± 0.05 vs. 0.80± 0.06, P = 0.012）, the ratio of E＇ to the late diastolic mitral annular velocity （EVA＇; 0.56 ± 0.12 vs. 0.51 ± 0.13, P 0.048）, and the ratio of the early diastolic mitral peak flow velocity （E） to E＇ （E/E＇; 10.70 ± 1.30 vs. 11.37 ± 1.73, P = 0.031）. After treatment, E/E＇ （ 10.70 ± 1.30 vs. 11.24± 1.56, P = 0.021 ）, deceleration time （DT; 261.49 ± 44.41 ms vs. 268.74 ±53.87 ms P = 0.046）, and EVA＇ （0.56 ± 0.12 vs. 0.52 ±0.13, P = 0.019） values improved more significantly than those of AM Group 2 before treatment. Besides, waist circumference was positively correlated with E＇ （r = 0.472, P = 0.003） and E＇/N （r = 0.321 ; P- 0.047）. In addition, the waist-to-hip ratio was a significant predictor ofDT （r = 0.276; P = 0.041）, E＇ （r= 0.590; P 〈 0.001 ）, E/E＇ （r = 0.454; P=0.004）, and EVA＇ （r= 0.377; P = 0.018）. Conclusions： Conventional medical plus AM therapy improved diastolic function. Moreover, WC and WH R might be risk ihctors tbr LVDD.

• Publisher: Wolters Kluwer India Pvt. Ltd,Medknow Publications and Media Pvt. Ltd,Lippincott Williams & Wilkins Ovid Technologies,Department of Cardiology, Lanzhou University Second Hospital, Lanzhou University, Lanzhou, Gansu 730000, China,Medknow Publications & Media Pvt Ltd,Wolters Kluwer
• Subject: Astragalus (Plant) / Astragalus Membranaceus; Hypertension; Left Ventricular Dysfunction; Metabolic Syndrome; Postmenopause / Atherosclerosis / Blood pressure / Cardiology / Cardiovascular diseases / Care and treatment / Chinese herbal medicine / Cholesterol / Clinical trials / Complications and side effects / Diabetes / Endocrinology / Family medical history / Health aspects / Hospitals / Hypertension / Kinases / Left ventricular function / Medical treatment / Mens health / Metabolic diseases / Metabolic syndrome / Mortality / Original / Patient outcomes / Postmenopausal women / Prevention / Risk factors / Rodents / Womens health / 机能障碍;新陈代谢;绝经后;高血压;症候群;随机化;心脏;控制