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Chemerin as a Potential Marker of Resolution of Inflammation in COVID-19 Infection

by Andrzej Surdacki , Barbara Wizner , Marek Sanak , Ivica Grgurevic , Joanna Sulicka-Grodzicka , Mariusz Korkosz , Monika Bociąga-Jasik , Kristian Podrug , Michał Kukla , Magdalena Strach , Lubomir Skladany , Marcin Surmiak , Wojciech Sydor

in adipokines / Angiopoietin / Asymptomatic / Biology (General) / Biomarkers / Body mass index / Cardiovascular disease / chemerin / chemerin ; resistin ; pentraxin 3 ; adipokines ; SARS-CoV2 ; specialized-pro-resolving mediators ; inflammation / Coronaviruses / COVID-19 / Cytokines / Hospitals / Infections / Inflammation / Kinases / Laboratories / Leptin / pentraxin 3 / Pentraxins / Proteins / QH301-705.5 / resistin / SARS-CoV2 / Severe acute respiratory syndrome coronavirus 2 / Software / specialized-pro-resolving mediators / Tumor necrosis factor-TNF / Tumor necrosis factor-α / Vascularization / Viral infections

2022

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Chemerin as a Potential Marker of Resolution of Inflammation in COVID-19 Infection

2022

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Chemerin as a Potential Marker of Resolution of Inflammation in COVID-19 Infection

2022

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Journal Article

Chemerin as a Potential Marker of Resolution of Inflammation in COVID-19 Infection

Andrzej Surdacki,

Barbara Wizner,

Marek Sanak,

Ivica Grgurevic,

Joanna Sulicka-Grodzicka,

Mariusz Korkosz,

Monika Bociąga-Jasik,

Kristian Podrug,

Michał Kukla,

Magdalena Strach,

Lubomir Skladany,

Marcin Surmiak,

Wojciech Sydor

2022

Overview

Chemerin is one of the specialized pro-resolving mediators that participate in the early phase of inflammation and contribute to the initiation of the pro-resolving response. There is a paucity of data regarding the time course of chemerin during acute infections. We aimed to evaluate the sequence of inflammatory responses in the acute COVID-19 phase throughout onset and resolution of inflammation. We evaluated changes in selected biomarkers in COVID-19 survivors on the 7-day and 28-day follow up. Chemerin was lower in patients with baseline moderate/severe disease at day 7 compared with asymptomatic patients and individuals with mild illness (7265 [5526–9448] vs. 8730 [6888–11,058] pg/mL; p = 0.03). Only in patients with moderate/severe disease, but not in those with mild symptoms, were chemerin concentrations decreased one week after infection onset compared with baseline (7265 [5526–9448] vs. 8866 [6383–10,690] pg/mL; p < 0.05) with a subsequent increase on the 28-day follow up (9313 [7353–11,033] pg/mL; p < 0.05). Resolution of inflammation in the group of moderate/severe SARS-CoV2 infection was associated with increasing serum concentrations of chemerin, contrary to pro-inflammatory cytokines and adipokines (pentraxin 3, TNFα, resistin, leptin). A similar pattern of angiopoietin-2 dynamics may suggest signs of enhanced vascularization as a consequence of acute SARS-CoV2 infection.

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Publisher

MDPI AG,MDPI

Subject

/ Cardiovascular disease