Journal Article

The role of cellular reactive oxygen species in cancer chemotherapy

Villani, Rehan M, Yang, Haotian, Wang, Haolu, Simpson, Matthew J, Tang, Min, Roberts, Michael S, Liang, Xiaowen

2018

Overview

Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer effect of these chemotherapeutics is due to the induction of oxidative stress and ROS-mediated cell injury in cancer. However, various new therapeutic approaches targeting intracellular ROS levels have yielded mixed results. Since it is impossible to quantitatively detect dynamic ROS levels in tumors during and after chemotherapy in clinical settings, it is of increasing interest to apply mathematical modeling techniques to predict ROS levels for understanding complex tumor biology during chemotherapy. This review outlines the current understanding of the role of ROS in cancer cells during carcinogenesis and during chemotherapy, provides a critical analysis of the methods used for quantitative ROS detection and discusses the application of mathematical modeling in predicting treatment responses. Finally, we provide insights on and perspectives for future development of effective therapeutic ROS-inducing anticancer agents or antioxidants for cancer treatment.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Apoptosis / Biomedical and Life Sciences / Biomedicine / Cancer / Cancer Research / Cell adhesion & migration / Cell cycle / Cell growth / Chemical bonds / Chemotherapy / Humans / Hypoxia / Immunology / Mathematical modeling / Melanoma / Metabolism / Metastasis / Neoplasms - drug therapy / Neoplasms - pathology / Oncology / Oxidative Stress / Reactive oxygen species / Reactive oxygen species (ROS) / Reactive Oxygen Species - metabolism / Redox / Review / ROS detection / Skin / Stem cells / Tumors