Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

by Stout, Kristen A , Burbulla, Lena F , Jyothisri, Kondapalli , Krainc Dimitri , James, Surmeier D , Schumacker, Paul T , Greengard, Paul , Zampese Enrico , Xie Zhong , Patriarchi Tommaso , Graves, Steven M , Lin, Tian , Shih, Jean C , Brichta Lars

in Amine oxidase (flavin-containing) / Anchoring / Dopamine / Electron transport / Electron transport chain / Hydrogen peroxide / Metabolism / Mitochondria / Oxidase / Oxidation

2020

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

in Amine oxidase (flavin-containing) / Anchoring / Dopamine / Electron transport / Electron transport chain / Hydrogen peroxide / Metabolism / Mitochondria / Oxidase / Oxidation

2020

Confirm

Do you wish to request the book?

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

in Amine oxidase (flavin-containing) / Anchoring / Dopamine / Electron transport / Electron transport chain / Hydrogen peroxide / Metabolism / Mitochondria / Oxidase / Oxidation

2020

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain

Stout, Kristen A,

Burbulla, Lena F,

Jyothisri, Kondapalli,

Krainc Dimitri,

James, Surmeier D,

Schumacker, Paul T,

Greengard, Paul,

Zampese Enrico,

Xie Zhong,

Patriarchi Tommaso,

Graves, Steven M,

Lin, Tian,

Shih, Jean C,

Brichta Lars

2020

Overview

Monoamine oxidase (MAO) metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate cytosolic hydrogen peroxide (H2O2). We show that MAO metabolism of DA does not increase cytosolic H2O2 but leads to mitochondrial electron transport chain (ETC) activity. This is dependent upon MAO anchoring to the outer mitochondrial membrane and shuttling electrons through the intermembrane space to support the bioenergetic demands of phasic DA release.Graves et al. demonstrate that as the neurotransmitter dopamine cycles through the cytosol at release sites, it can be metabolized by a mitochondrial enzyme to help generate the energy necessary to sustain synaptic function.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group

Subject

Amine oxidase (flavin-containing)

/ Anchoring

/ Dopamine

/ Electron transport

/ Electron transport chain

/ Hydrogen peroxide

/ Metabolism