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Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo
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Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo
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Journal Article
Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo
2017
Overview
Background
Cationic antibacterial peptides (CAPs) and synthetic molecules mimicking the amphiphilic structure of CAPs, such as ceragenins, are promising compounds for the development of new antimicrobials.
Results
We tested the in vitro activity of ceragenins CSA-13 and CSA-131 against several anaerobic bacteria including
Bacteroides
spp. and
Clostridium difficile
. We compared results to the activity of cathelicidin LL-37, metronidazole and nanosystems developed by attachment of CSA-13 and CSA-131 to magnetic nanoparticles (MNPs). The antibacterial effect was tested using killing assay and modified CLSI broth microdilution assay. Ceragenins CSA-13 and CSA-131 displayed stronger bactericidal activity than LL-37 or metronidazole against all of the tested bacterial strains. Additionally CSA-131 revealed an enhanced ability to prevent the formation of
Bacteroides fragilis
and
Propionibacterium acnes
biofilms.
Conclusions
These data confirmed that ceragenins display antimicrobial activity against a broad range of microorganisms including anaerobic bacteria and deserve further investigations as compounds serving to develop new treatment against anaerobic and mixed infections.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Analysis
/ Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - pharmacology
/ Antiinfectives and antibacterials
/ Antimicrobial Cationic Peptides - chemistry
/ Antimicrobial Cationic Peptides - pharmacology
/ Bacteria
/ Bacteria, Anaerobic - drug effects
/ Bacteria, Anaerobic - growth & development
/ Biofilms
/ Biomedical and Life Sciences
/ Clinical microbiology and vaccines
/ Diarrhea
/ Magnetite Nanoparticles - chemistry
/ Mimicry
/ Mycology
/ Peptides
/ Skin
/ Virology
