Journal Article

Evaluation of the efficacy of mesenchymal stem cells derived conditioned medium in the treatment of striae distensae: a double blind randomized clinical trial

Dehghani, Abbas, Behrangi, Elham, Goodarzi, Azadeh, Zare, Sona, Feizollahi, Masoomeh, Zeinali, Roya, Ghasemi, Mohammad Reza, Nouri, Maryam, Roohaninasab, Masoomeh, Nilforoushzadeh, Mohammad Ali, Sadeghzadeh-Bazargan, Afsaneh

2024

Overview

Background Striae distensae is a disfiguring atrophic skin condition that impairs the body’s aesthetic image. Despite the variety of conducted studies, there is controversy regarding the best modalities. Human mesenchymal stem cells are considered a rich source for scar treatment. Skin needling is among the most efficient and safe aesthetic and therapeutic devices. This study aimed to evaluate the efficacy of the combination of needling and intradermal injection of mesenchymal stem cells compared to skin needling alone for treating striae distensae. Method This study was a randomized, double-blind clinical trial involving 10 women aged 18–60. Each striae lesion was divided into two parts, with one side receiving needling and intradermal injection of conditioned medium, while the other side received needling and intradermal injection of normal saline. This treatment was administered in three sessions with three-week intervals. Patients were evaluated before the first intervention and three months after the final session. Three months after the completion of the intervention, patients’ lesions were evaluated using biometric criteria, physician evaluation, and patient self-assessment. Results The results demonstrated a significant improvement in dermal and complete thickness and skin density in patients treated with microneedling. All skin ultrasound parameters improved significantly in patients receiving the combination of needling and conditioned medium. When comparing the two groups, significantly higher physician and patient satisfaction was observed in the combination group. However, the comparison of biometric indices improvement wasn’t significant between these groups. Conclusion The combination of human mesenchymal stem cells with microneedling could be considered a novel effective option for stretch marks.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Abdomen / Antibiotics / Biomedical and Life Sciences / Biomedical Engineering and Bioengineering / Biometrics / Cell Biology / Cell culture / Cicatrix / Clinical trial / Clinical trials / Collagen / Comparative analysis / Conditioned medium / Culture Media, Conditioned - pharmacology / Double-Blind Method / Efficacy / Extracellular matrix / Female / Health aspects / Humans / Intervention / Lasers / Life Sciences / Mesenchymal Stem Cells / Microneedling / Patient satisfaction / Patients / Penicillin / Performance evaluation / Regenerative Medicine/Tissue Engineering / Self-assessment / Skin / Skin diseases / Stem Cells / Striae / Striae distensae / Striae Distensae - therapy / Transplantation / Umbilical cord