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Mitochondrial transplantation in humans: “magical” cure or cause for concern?
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Mitochondrial transplantation in humans: “magical” cure or cause for concern?
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Journal Article
Mitochondrial transplantation in humans: “magical” cure or cause for concern?
2018
Overview
[...]enough mitochondria must pass through the cell membrane to contribute to ATP production by the host cell. Because the study was so small, it is unclear whether the published 20% mortality rate with mitochondrial transplantation is an improvement over the 38%-40% overall mortality rate for pediatric patients on ECMO in large hospitals (18). [...]in animal studies, only a miniscule number of mitochondria are found to be colocalized with cardiac cells, let alone internalized - far too few to impact tissue ATP production. [...]even if the extracellular mitochondria remained viable and were producing ATP, this ATP would not be available to boost cardiac contractile function, which is inconsistent with rapid improvements in the hemodynamic parameters described in the animal studies (4-6). [...]we would like to express our concern regarding the recent application of this technique to pediatric patients and the increasing media coverage of mitochondrial transplantation.
