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Neuropathology of incidental Lewy body & prodromal Parkinson’s disease
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Neuropathology of incidental Lewy body & prodromal Parkinson’s disease
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Journal Article
Neuropathology of incidental Lewy body & prodromal Parkinson’s disease
2023
Overview
Background
Parkinson’s disease (PD) is a progressive neurodegenerative disorder associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there is currently no disease-modifying treatment to halt neuronal loss in PD. A major hurdle for developing and testing such curative therapies results from the fact that most DA neurons are already lost at the time of the clinical diagnosis, rendering them inaccessible to therapy. Understanding the early pathological changes that precede Lewy body pathology (LBP) and cell loss in PD will likely support the identification of novel diagnostic and therapeutic strategies and help to differentiate LBP-dependent and -independent alterations. Several previous studies identified such specific molecular and cellular changes that occur prior to the appearance of Lewy bodies (LBs) in DA neurons, but a concise map of such early disease events is currently missing.
Methods
Here, we conducted a literature review to identify and discuss the results of previous studies that investigated cases with incidental Lewy body disease (iLBD), a presumed pathological precursor of PD.
Results
Collectively, our review demonstrates numerous cellular and molecular neuropathological changes occurring prior to the appearance of LBs in DA neurons.
Conclusions
Our review provides the reader with a summary of early pathological events in PD that may support the identification of novel therapeutic and diagnostic targets and aid to the development of disease-modifying strategies in PD.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
/ Biomedical and Life Sciences
/ Dementia
/ Enteric nervous system (ENS)
/ Humans
/ Incidental Lewy body disease (iLBD)
/ Lewy Body Disease - pathology
/ Mutation
/ Nerve Degeneration - pathology
/ Neurons
/ Parkinson Disease - pathology
/ Prodromal Parkinson’s disease (PD)
/ Proteins
/ REM-sleep behaviour disorder (RBD)
/ Review
