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Trends in body mass index in the pre-dolutegravir period in South Africa
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Trends in body mass index in the pre-dolutegravir period in South Africa
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Journal Article
Trends in body mass index in the pre-dolutegravir period in South Africa
2024
Overview
BackgroundAntiretroviral therapy (ART) is associated with weight gain, but this has been shown to be more marked with dolutegravir and other integrase strand transfer inhibitors.ObjectivesWe studied weight gain in people living with HIV (PLWH) on ART compared to the general population in the period before dolutegravir was introduced in a rural South African cohort.MethodLongitudinal analysis of the Ndlovu Cohort Study including 36–48 months’ follow-up data. From 2014 to 2019, data were collected annually in Limpopo, rural South Africa. Linear mixed models using HIV status, demographics, ART use and cardiovascular risk factors were used to estimate trends in body mass index (BMI) over time.ResultsIn total, 1518 adult, non-pregnant participants were included, of whom 518 were PLWH on ART (79.8%), 135 PLWH not yet on ART (20.2%) and 865 HIV-negative. HIV-negative participants had significantly higher BMIs than PLWH on ART at all study visits. There was a significant increase in BMI in all subgroups after 36 months (PLWH on ART, BMI +1.2 kg/m2, P < 0.001; PLWH not on ART, BMI +1.8 kg/m2, P < 0.001 and HIV-negative, BMI +1.3 kg/m2, P < 0.001).ConclusionThe increase in BMI in PLWH and HIV-negative participants is a serious warning signal as obesity results in morbidity and mortality.
Publisher
AOSIS,African Online Scientific Information Systems (Pty) Ltd t/a AOSIS,AOSIS (Pty) Ltd,Southern African HIV Clinicians Society
