Asset Details
Do you wish to reserve the book?
Clinical outcomes in hospitalized patients with community-acquired pneumonia: A comprehensive analysis of associated factors
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Clinical outcomes in hospitalized patients with community-acquired pneumonia: A comprehensive analysis of associated factors
Do you wish to request the book?
Clinical outcomes in hospitalized patients with community-acquired pneumonia: A comprehensive analysis of associated factors
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Clinical outcomes in hospitalized patients with community-acquired pneumonia: A comprehensive analysis of associated factors
2026
Overview
Background: Community-acquired pneumonia (CAP) remains a significant
cause of hospitalization and mortality globally. Optimizing clinical outcomes in
CAP depends heavily on timely, appropriate empiric antibiotic therapy.
However, limited data from low- and middle-income countries hinder effective
stewardship efforts. The study aims to assess clinical outcomes among
hospitalized CAP patients in Lebanon and identify key factors associated with
deterioration or death, with particular emphasis on the role of guideline
concordant empiric antibiotic prescribing.
Methods: A cross-sectional study was conducted in five tertiary hospitals across
Lebanon between January and June 2024. Adult patients admitted with CAP
were included. Demographic, clinical, laboratory, microbiological, and
treatment data were extracted. Antibiotic regimens were evaluated for
adherence to national CAP guidelines. Multivariable logistic regression was
used to identify predictors of poor clinical outcomes, defined as ICU admission
or in-hospital death.
Results: Inappropriate antibiotic selection (aOR=18.81, p< 0.001) and dosing
(aOR=1.78, p=0.027) were significantly associated with poor outcomes.
Additional predictors included advanced age, congestive heart failure, coronary
artery disease, elevated WBC, and CURB-65 scores ≥ 3. Conversely, patients with
classical CAP presentations (e.g., wheezing, rales) were more likely to
experience favorable outcomes.
Conclusion: Inappropriate empiric antibiotic prescribing significantly worsens
clinical outcomes in hospitalized CAP patients. These findings underscore the
urgent need for strengthening antimicrobial stewardship programs,
implementing clinical decision support tools, and reinforcing physician
education to promote adherence to national guidelines and improve patient
safety.
Publisher
Public Library of Science,PLOS,Public Library of Science (PLoS)
Subject
