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A Wolbachia triple-strain infection generates self-incompatibility in Aedes albopictus and transmission instability in Aedes aegypti
by
Ant, Thomas H.
, Sinkins, Steven P.
in
Aedes - genetics
/ Aedes - microbiology
/ Aedes - physiology
/ Aedes aegypti
/ Aedes albopictus
/ Animals
/ bacteria
/ Biomedical and Life Sciences
/ Biomedicine
/ Cytoplasmic-incompatibility
/ dengue
/ Disease transmission
/ Entomology
/ Female
/ Health aspects
/ Host-parasite relationships
/ Infectious Diseases
/ Insect Vectors - genetics
/ Insect Vectors - microbiology
/ Insect Vectors - physiology
/ Male
/ Medical research
/ mixed infection
/ Parasitology
/ Population-replacement
/ Reproduction
/ species
/ Superinfection
/ Tropical Medicine
/ vectorial capacity
/ Veterinary Medicine/Veterinary Science
/ Virology
/ Wolbachia
/ Wolbachia - physiology
/ Wolbachia pipientis
/ Yellow fever mosquito
2018
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A Wolbachia triple-strain infection generates self-incompatibility in Aedes albopictus and transmission instability in Aedes aegypti
by
Ant, Thomas H.
, Sinkins, Steven P.
in
Aedes - genetics
/ Aedes - microbiology
/ Aedes - physiology
/ Aedes aegypti
/ Aedes albopictus
/ Animals
/ bacteria
/ Biomedical and Life Sciences
/ Biomedicine
/ Cytoplasmic-incompatibility
/ dengue
/ Disease transmission
/ Entomology
/ Female
/ Health aspects
/ Host-parasite relationships
/ Infectious Diseases
/ Insect Vectors - genetics
/ Insect Vectors - microbiology
/ Insect Vectors - physiology
/ Male
/ Medical research
/ mixed infection
/ Parasitology
/ Population-replacement
/ Reproduction
/ species
/ Superinfection
/ Tropical Medicine
/ vectorial capacity
/ Veterinary Medicine/Veterinary Science
/ Virology
/ Wolbachia
/ Wolbachia - physiology
/ Wolbachia pipientis
/ Yellow fever mosquito
2018
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A Wolbachia triple-strain infection generates self-incompatibility in Aedes albopictus and transmission instability in Aedes aegypti
by
Ant, Thomas H.
, Sinkins, Steven P.
in
Aedes - genetics
/ Aedes - microbiology
/ Aedes - physiology
/ Aedes aegypti
/ Aedes albopictus
/ Animals
/ bacteria
/ Biomedical and Life Sciences
/ Biomedicine
/ Cytoplasmic-incompatibility
/ dengue
/ Disease transmission
/ Entomology
/ Female
/ Health aspects
/ Host-parasite relationships
/ Infectious Diseases
/ Insect Vectors - genetics
/ Insect Vectors - microbiology
/ Insect Vectors - physiology
/ Male
/ Medical research
/ mixed infection
/ Parasitology
/ Population-replacement
/ Reproduction
/ species
/ Superinfection
/ Tropical Medicine
/ vectorial capacity
/ Veterinary Medicine/Veterinary Science
/ Virology
/ Wolbachia
/ Wolbachia - physiology
/ Wolbachia pipientis
/ Yellow fever mosquito
2018
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A Wolbachia triple-strain infection generates self-incompatibility in Aedes albopictus and transmission instability in Aedes aegypti
Journal Article
A Wolbachia triple-strain infection generates self-incompatibility in Aedes albopictus and transmission instability in Aedes aegypti
2018
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Overview
Background
Artificially-introduced transinfections of the intracellular bacterium
Wolbachia pipientis
have the potential to reduce the vectorial capacity of mosquito populations for viruses such as dengue and chikungunya.
Aedes albopictus
has two native strains of
Wolbachia
, but their replacement with the non-native
w
Mel strain blocks transmission of both viruses. The pattern of cytoplasmic incompatiiblity generated by
w
Mel with wild-types is bidirectional. Novel-plus-native-strain co-infection is predicted to lead to a more efficient population spread capacity; from a bi-directional to a uni-directional cytoplasmic incompatibility (CI) model.
Results
A novel-plus-native-strain triple-infection in
Ae. albopictus
(
w
AlbA
w
AlbB
w
Mel) was generated. Although triple-infected females were fully reproductively viable with uninfected males, they displayed self-incompatibility. qPCR of specific strains in dissected tissues suggested that this may be due to the displacement of one of the native strains (
w
AlbA) from the ovaries of triple-infected females. When the triple strain infection was transferred into
Aedes aegypti
it displayed an unexpectedly low level of transmission fidelity of the three strains in this species.
Conclusions
These results suggest that combining
Wolbachia
strains can lead to co-infection interactions that can affect outcomes of CI and maternal transmission.
Publisher
BioMed Central,BioMed Central Ltd,BMC
Subject
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