Asset Details
Do you wish to reserve the book?
Inhibitory effects of nafcillin and diosmin on biofilm formation by Salmonella Typhimurium
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Inhibitory effects of nafcillin and diosmin on biofilm formation by Salmonella Typhimurium
Do you wish to request the book?
Inhibitory effects of nafcillin and diosmin on biofilm formation by Salmonella Typhimurium
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Inhibitory effects of nafcillin and diosmin on biofilm formation by Salmonella Typhimurium
2024
Overview
Objective
The foodborne pathogen
Salmonella
enterica serovar Typhimurium causes self-limiting gastroenteritis in humans and is difficult to eliminate due to its ability to adhere to surfaces and form biofilms that exhibit high resistance to antimicrobial agents. To explore alternative strategies for biofilm treatment, it is essential to investigate novel agents that inhibit
Salmonella
biofilms.
Method
In this study, we investigated the minimum biofilm inhibitory concentrations (MBICs) and minimum biofilm eradication concentrations (MBECs) of nafcillin and diosmin, both previously identified as Lon protease inhibitors, against biofilms formed by
S
. Typhimurium. Furthermore, we examined the expression of genes associated with the type II toxin-antitoxin system to enhance our understanding of the impact of these inhibitors.
Results
The findings indicated a strong antibiofilm effect of nafcillin, with MBIC and MBEC values of 8 µg/mL and 32 µg/mL, respectively. These results were confirmed by field emission scanning electron microscopy (FE-SEM), which showed that biofilm formation was reduced in the presence of nafcillin. Additionally, it revealed morphological changes in the bacteria within the nafcillin-treated biofilms. Furthermore, gene expression analyses demonstrated a significant reduction in the expression of type II TA system genes following treatment with nafcillin and diosmin.
Conclusion
This study highlights the effectiveness of nafcillin in disrupting the biofilms of
S
. Typhimurium. These results suggest promising avenues for the development of novel therapeutic strategies targeting biofilms associated with
S
. Typhimurium.
Publisher
BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
Subject
Anti-Bacterial Agents - pharmacology
/ Bacteria
/ Bacterial Proteins - genetics
/ Bacterial Proteins - metabolism
/ Biofilm
/ Biofilms
/ Biomedical and Life Sciences
/ Chloride
/ Control
/ Diosmin
/ Flavones
/ Gene Expression Regulation, Bacterial - drug effects
/ Genes
/ Microscopy, Electron, Scanning
/ Mycology
/ Salmonella typhimurium - drug effects
/ Salmonella typhimurium - genetics
/ Salmonella typhimurium - physiology
/ Scanning electron microscopy
/ Sodium
/ Toxins
/ Virology
