Asset Details
Do you wish to reserve the book?
EPHX1 and ERCC2 polymorphisms are associated with cisplatin-induced nephrotoxicity and prognosis in Thai cancer patients
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
EPHX1 and ERCC2 polymorphisms are associated with cisplatin-induced nephrotoxicity and prognosis in Thai cancer patients
Do you wish to request the book?
EPHX1 and ERCC2 polymorphisms are associated with cisplatin-induced nephrotoxicity and prognosis in Thai cancer patients
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
EPHX1 and ERCC2 polymorphisms are associated with cisplatin-induced nephrotoxicity and prognosis in Thai cancer patients
2025
Overview
Cisplatin is a widely used chemotherapeutic drug for various cancers. One of the common adverse effects of cisplatin is nephrotoxicity including acute kidney injury (AKI) and acute kidney disease (AKD). Single Nucleotide Polymorphisms (SNPs) can be used to identify cancer patients who are susceptible to developing cisplatin-induced nephrotoxicity (CIN). In this study, we validated the association between 6 SNPs in the drug metabolizing enzyme genes, SLC22A2 (rs316019) & EPHX1 (rs1051740), and the DNA repair genes, ERCC1 (rs11615 & rs3212986) & ERCC2 (rs13181 & rs1799793), and CIN in the 169 Thai patients with head and neck, lung, or esophageal cancer. Effect of these SNPs on cumulative incidence of AKD, progression-free survival (PFS), and overall survival (OS) was also assessed. EPHX1 rs1051740 TC genotype was significantly associated with AKD in co-dominant [OR 2.894, 95% CI 1.091–7.680; P = 0.033] and over-dominant [OR 2.793, 95% CI 1.333–5.851; P = 0.006] models, and with an increased cumulative incidence of AKD ( P = 0.021). Additionally, ERCC2 rs13181 and rs1799793 were significantly associated with OS ( P = 0.002 and 0.004). Our results reveal an association between EPHX1 rs1051740 and AKD, and confirms the previously reported associations between ERCC2 SNPs and OS. These findings may help in predicting CIN in Thai cancer patients.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
Acute Kidney Injury - chemically induced
/ Acute Kidney Injury - genetics
/ Adult
/ Aged
/ Analysis
/ Antineoplastic Agents - adverse effects
/ Biobanks
/ Cancer
/ Complications and side effects
/ DNA-Binding Proteins - genetics
/ Enzymes
/ Female
/ Genes
/ Genetic Predisposition to Disease
/ Genotype
/ Humans
/ Kidneys
/ Male
/ Medicine and Health Sciences
/ Organic Cation Transporter 2 - genetics
/ Patients
/ Polymorphism, Single Nucleotide
/ Single nucleotide polymorphisms
/ Single-nucleotide polymorphism
/ Survival
/ Thailand
