Journal Article

Global burden, health inequalities and improvement gap of head and neck cancers in middle-aged and older adults from 1990 to 2021

Xuan, Feng, Ma, Xiaofeng, Qiu, Zhaoqi, Yang, Minxia

2025

Overview

This study aimed to assess temporal trends, health inequities and potential improvements in the burden of head and neck cancer (HNC) in middle-aged and older adults between 1990 and 2021, focusing on three major subtypes: larynx, nasopharynx, and lip/oral cavity cancers. A secondary analysis of the Global Burden of Disease Study (GBD) 2021 was performed, using age-standardised incidence rates (ASIR) and age-standardised disability-adjusted life years (ASDR) to quantify the burden of HNC. The average annual percent change was calculated to analyzed trends. The slope index of inequality (SII) and the concentration index quantified health inequities. Frontier analysis identified regions with potential for improvement. In 2021, there were approximately 650,205 new cases of overall HNC globally, resulting in 9,621,610 DALYs, with ASIR and ASDR both declining since 1990. ASIR exhibited a decrease for laryngeal and nasopharyngeal cancers, in contrast to an increase for lip and oral cavity cancers. ASDR decreased across all cancer types. The SII showed a notable shift in ASDR from countries with higher socio-demographic indices (SDI) in 1990 to those with lower SDI countries by 2021. Meantime, the concentration index revealed a worsening inequality in lower SDI countries. Frontier analyses across 204 countries and territories indicated that certain high SDI countries could effectively reduce ASDR for HNCs. The global burden of HNCs shown considerable regional disparities. Health inequalities have persisted, with lower SDI regions bearing a heavier burden, particularly in laryngeal and lip/oral cavity cancers. Developing tailored national cancer control plans and enhancing international medical cooperation are essential to reduce HNC burden and promote equitable health outcomes.

• Publisher: Public Library of Science,PLOS,Public Library of Science (PLoS)
• Subject: Adults / Age / Aged / Analysis / Biology and Life Sciences / Cancer / Care and treatment / Demographic aspects / Development and progression / Diagnosis / Disability-Adjusted Life Years / Female / Forecasts and trends / Global Burden of Disease - trends / Global Health / Head & neck cancer / Head and neck / Head and neck cancer / Head and Neck Neoplasms - epidemiology / Health aspects / Health care disparities / Health disparities / Health Status Disparities / Humans / Incidence / Inequalities / Laryngeal cancer / Larynx / Lip / Male / Medical research / Medicine and Health Sciences / Medicine, Experimental / Middle Aged / Nasopharynx / Older people / Oral cavity / People and Places / Quality of life / Secondary analysis / Sociodemographics / Socioeconomic Factors / Trends