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Association Between Maternal Factors and Risk of Congenital Heart Disease in Offspring: A Systematic Review and Meta-Analysis
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Association Between Maternal Factors and Risk of Congenital Heart Disease in Offspring: A Systematic Review and Meta-Analysis
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Journal Article
Association Between Maternal Factors and Risk of Congenital Heart Disease in Offspring: A Systematic Review and Meta-Analysis
2023
Overview
IntroductionThis study aimed to summarize the evidence describing the relationship between maternal factors during gestation and risk of congenital heart disease (CHD) in offspring.MethodsPubMed, EMBASE, and the Cochrane Library were searched for potentially relevant reports from inception to May 2021. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) calculated by the random-effects model were used to evaluate the association between maternal factors and CHD risk.ResultsThere was a significant association between CHD risk and obesity in pregnancy (OR 1.29, 95% CI 1.22–1.37; P < 0.001), smoking in pregnancy (OR 1.16, 95% CI 1.07–1.25; P < 0.001), maternal diabetes (OR 2.65, 95% CI 2.20–3.19; P < 0.001), and exposure of pregnant women to organic solvents (OR 1.82, 95% CI 1.23–2.70; P = 0.003). No correlations were revealed between CHD susceptibility and advanced maternal age (OR 1.04, 95% CI 0.96–1.12; P = 0.328), underweight (OR 1.02, 95% CI 0.96–1.08; P = 0.519), alcohol intake in pregnancy (OR 1.08, 95% CI 0.95–1.22; P = 0.251), coffee intake (OR 1.18, 95% CI 0.97–1.44; P = 0.105), and exposure to irradiation (OR 1.80, 95% CI 0.85–3.80; P = 0.125).DiscussionMaternal factors including maternal obesity, smoking in pregnancy, maternal diabetes and exposure to organic solvents might predispose the offspring to CHD risk.
Publisher
Springer Nature B.V
