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Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

by Filipowicz, Witold , Zoller, Tabea , Cougot, Nicolas , Basyuk, Eugenia , Bertrand, Edouard , Bhattacharyya, Suvendra N , Artus, Caroline G , Pillai, Ramesh S

in 3' untranslated regions / Animalia / Argonaute Proteins / Biochemistry, Molecular Biology / Cells / Cells (Biology) / Cellular structures / Eukaryotes / eukaryotic cells / Eukaryotic Initiation Factor-2 / Fractions / Gene expression / Gene expression regulation / HeLa Cells / Humans / Inhibition / Journalism / Life Sciences / Messenger RNA / MicroRNA / MicroRNAs - analysis / MicroRNAs - physiology / Molecules / Oligonucleotides / Peptide Chain Initiation, Translational / Peptide Initiation Factors - analysis / Peptide Initiation Factors - physiology / Proteins / Repression / Ribonucleic acid / Ribonucleoproteins - analysis / Ribonucleoproteins - physiology / Ribosomes / RNA / RNA Caps - metabolism / RNA, Messenger - analysis / Translation / translation (genetics)

2005

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Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

by Filipowicz, Witold , Zoller, Tabea , Cougot, Nicolas , Basyuk, Eugenia , Bertrand, Edouard , Bhattacharyya, Suvendra N , Artus, Caroline G , Pillai, Ramesh S

2005

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Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

by Filipowicz, Witold , Zoller, Tabea , Cougot, Nicolas , Basyuk, Eugenia , Bertrand, Edouard , Bhattacharyya, Suvendra N , Artus, Caroline G , Pillai, Ramesh S

2005

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Journal Article

Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells

Filipowicz, Witold,

Zoller, Tabea,

Cougot, Nicolas,

Basyuk, Eugenia,

Bertrand, Edouard,

Bhattacharyya, Suvendra N,

Artus, Caroline G,

Pillai, Ramesh S

2005

Overview

MicroRNAs (miRNAs) are [approximately]21-nucleotide-long RNA molecules regulating gene expression in multicellular eukaryotes. In metazoa, miRNAs act by imperfectly base-pairing with the 3' untranslated region of target messenger RNAs (mRNAs) and repressing protein accumulation by an unknown mechanism. We demonstrate that endogenous let-7 microribonucleoproteins (miRNPs) or the tethering of Argonaute (Ago) proteins to reporter mRNAs in human cells inhibit translation initiation. M⁷G-cap-independent translation is not subject to repression, suggesting that miRNPs interfere with recognition of the cap. Repressed mRNAs, Ago proteins, and miRNAs were all found to accumulate in processing bodies. We propose that localization of mRNAs to these structures is a consequence of translational repression.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science,American Association for the Advancement of Science (AAAS)

Subject

3' untranslated regions

/ Animalia

/ Argonaute Proteins

/ Biochemistry, Molecular Biology

/ Cells

/ Cells (Biology)

/ Cellular structures

/ Eukaryotes

/ eukaryotic cells

/ Eukaryotic Initiation Factor-2

/ Fractions