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Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model
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Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model
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Journal Article
Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model
2015
Overview
Background
The human gut houses one of the most complex and abundant ecosystems composed of up to 10
13
-10
14
microorganisms. The importance of this intestinal microbiota is highlighted when a disruption of the intestinal ecosystem equilibrium appears (a phenomenon called dysbiosis) leading to an illness status, such as inflammatory bowel diseases (IBD). Indeed, the reduction of the commensal bacterium
Faecalibacterium prausnitzii
(one of the most prevalent intestinal bacterial species in healthy adults) has been correlated with several diseases, including IBD, and most importantly, it has been shown that this bacterium has anti-inflammatory and protective effects in pre-clinical models of colitis. Some dysbiosis disorders are characterized by functional and physiological alterations. Here, we report the beneficial effects of
F. prausnitzii
in the physiological changes induced by a chronic low-grade inflammation in a murine model. Chronic low-grade inflammation and gut dysfunction were induced in mice by two episodes of dinitro-benzene sulfonic acid (DNBS) instillations. Markers of inflammation, gut permeability, colonic serotonin and cytokine levels were studied. The effects of
F. prausnitzii
strain A2-165 and its culture supernatant (SN) were then investigated.
Results
No significant differences were observed in classical inflammation markers confirming that inflammation was subclinical. However, gut permeability, colonic serotonin levels and the colonic levels of the cytokines IL-6, INF-γ, IL-4 and IL-22 were higher in DNBS-treated than in untreated mice. Importantly, mice treated with either
F. prausnitzii
or its SN exhibited significant decreases in intestinal permeability, tissue cytokines and serotonin levels.
Conclusions
Our results show that
F. prausnitzii
and its SN had beneficial effects on intestinal epithelial barrier impairment in a chronic low-grade inflammation model. These observations confirm the potential of this bacterium as a novel probiotic treatment in the management of gut dysfunction and low-grade inflammation.
Publisher
BioMed Central,BioMed Central Ltd
