Journal Article

Genetic diversity in the modern horse illustrated from genome-wide SNP data

Mccue, Molly E, National Research Initiative from the United States Department of Agriculture-National Institute of Food and Agriculture (USDA-NIFA) [2008-35205-18766, 2009-55205-05254, 2012-67015-19432]; Foundation for the Advancement of the Tennessee Walking Show Horse; Tennessee Walking Horse Foundation; National Institutes of Health-National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIHNAIMS) [1K08AR055713-01A2, 2T32AR007612]; American Quarter Horse Foundation; Morris Animal Foundation [D07EQ-500]; Swedish Research Council FORMAS [221-2009-1631, 2008-617]; Swedish-Norwegian Foundation for Equine Research [H0847211, H0947256]; Carl Tryggers Stiftelse [CTS 08: 29]; FCT; DRCT; Science Foundation Ireland [04/Y11/B539]; Volkswagen Stiftung und Niedersa chsisches Ministerium fur Wissenschaft und Kultur, Germany [VWZN2012]; [FRCT/2011/317/005], The University of Sydney, Felicetti, Michela, Hill, Emmeline W, Vaudin, Mark, Fac Vet Med ; Università degli Studi di Perugia = University

2013

Overview

Horses were domesticated from the Eurasian steppes 5,000-6,000 years ago. Since then, the use of horses for transportation, warfare, and agriculture, as well as selection for desired traits and fitness, has resulted in diverse populations distributed across the world, many of which have become or are in the process of becoming formally organized into closed, breeding populations (breeds). This report describes the use of a genome-wide set of autosomal SNPs and 814 horses from 36 breeds to provide the first detailed description of equine breed diversity. FST calculations, parsimony, and distance analysis demonstrated relationships among the breeds that largely reflect geographic origins and known breed histories. Low levels of population divergence were observed between breeds that are relatively early on in the process of breed development, and between those with high levels of within-breed diversity, whether due to large population size, ongoing outcrossing, or large within-breed phenotypic diversity. Populations with low within-breed diversity included those which have experienced population bottlenecks, have been under intense selective pressure, or are closed populations with long breed histories. These results provide new insights into the relationships among and the diversity within breeds of horses. In addition these results will facilitate future genome-wide association studies and investigations into genomic targets of selection.

• Publisher: CCSD,Public Library of Science,Public Library of Science (PLoS)
• Subject: Agriculture / Analysis / Animal breeding / Animals / Biodiversity / Bioengineering / Bioinformatics / Biology / Biotechnology / Breeding / Breeding of animals / Cluster Analysis / Deoxyribonucleic acid / Divergence / DNA / Domestication / Fitness / Food science / Genetic diversity / Genetics and Breeding / Genetik och förädling / Genome-wide association studies / Genomes / Genomics / Horses / Horses - classification / Horses - genetics / Integrated software / Laboratories / Life Sciences / Medical research / Mitochondrial DNA / Neuromuscular diseases / Polymorphism, Single Nucleotide / Population genetics / Population number / Populations / Principal Component Analysis / Reproductive fitness / Single-nucleotide polymorphism / Steppes / Studies / Veterinary colleges / Veterinary medicine / Veterinary Science / Warfare
• ISBN: 0003155638000