Journal Article

Role of fluid-phase complement system regulation in the development of hepatitis C virus-associated glomerulonephritis

Adam, Ahmed G., Ibrahim, Sara T., Baddour, Nahed, Abdelhamid, Marwa R., Lewis, Neveen

2022

Overview

It is not known why only some hepatitis C virus (HCV) infected patients develop glomerulonephritis (GN). Therefore, we investigated the role of soluble complement regulators in the development of HCV associated GN. Serum levels of complement 4 binding protein (C4BP) were significantly lower in group 1 (median 70 ng/ml) than in groups 2 (median 88.8 ng/ml) and 3 (median 82.8 ng/ml) with p value of 0.007. The minor allele (allele A) of rs800292 for CFH was significantly higher in group 2 and group 3 (G 54% and A 46%) than in group 1 (G 73% and A 27%), p = 0.04. Low C4BP levels are associated with GN in HCV infected patients. In addition, rs800292 SNP in CFH protects against GN in patients with HCV.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Alleles / Antibodies / Biology and life sciences / Biopsy / Care and treatment / Chronic illnesses / Complement / Complement component C3 / Complement factor H / Complement system / Creatinine / Deoxyribonucleic acid / Diabetes / Diagnosis / DNA / Enzyme-linked immunosorbent assay / Glomerulonephritis / Hepatitis / Hepatitis C / Hepatitis C virus / HIV / Human immunodeficiency virus / Infections / Kidney diseases / Laboratories / Medicine and health sciences / Nucleotides / Patient outcomes / Polymerase chain reaction / Proteins / Research and Analysis Methods / Serum levels / Single-nucleotide polymorphism / Urine / Viruses