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Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system
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Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system
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Journal Article
Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system
2014
Overview
Editing the genome of a malarial parasite with Cas9 validates a drug-resistance polymorphism
Genome manipulation in the malaria parasite
Plasmodium falciparum
remains largely intractable and improved genomic tools are needed to further understand pathogenesis and drug resistance. We demonstrated the CRISPR-Cas9 system for use in
P. falciparum
by disrupting chromosomal loci and generating marker-free, single-nucleotide substitutions with high efficiency. Additionally, an artemisinin-resistant strain was generated by introducing a previously implicated polymorphism, thus illustrating the value of efficient genome editing in malaria research.
Publisher
Nature Publishing Group US,Nature Publishing Group
