Journal Article

Cereal Fiber Improves Whole-Body Insulin Sensitivity in Overweight and Obese Women

Viehoff, Hannah, Otto, Bärbel, Koebnick, Corinna, Kohl, Angela, Spranger, Joachim, Pfeiffer, Andreas F.H, Arafat, Ayman M, Weickert, Martin O, Schöfl, Christof, Möhlig, Matthias

2006

Overview

OBJECTIVE:--Cereal fiber intake is linked to reduced risk of type 2 diabetes in epidemiological observations. The pathogenic background of this phenomenon is unknown. Based on recent findings, we hypothesized that intake of purified insoluble oat fiber may improve whole-body insulin sensitivity. RESEARCH DESIGN AND METHODS--A randomized, controlled, single-blind, cross-over study was performed, and 17 overweight or obese subjects with normal glucose metabolism were analyzed. After consumption of nine macronutrient-matched portions of fiber-enriched bread (white bread enriched with 31.2 g insoluble fiber/day) or control (white bread) over a time period of 72 h, whole-body insulin sensitivity was assessed by euglycemic-hyperinsulinemic clamp. Energy intake was individually adjusted by providing standardized liquid meals. Hydrogen breath tests were performed to control for dietary adherence. RESULTS:--When analyzing the entire cohort, whole-body glucose disposal was improved after fiber consumption (M value 6.56 ± 0.32 vs. 6.07 ± 0.27 mg · min⁻¹ · kg⁻¹; P = 0.043). Thirteen subjects had increased hydrogen breath test concentrations after fiber consumption, indicating probable dietary adherence. Restricting analysis to these subjects, improvements in M value (6.85 ± 0.34 vs. 6.06 ± 0.32 mg · min⁻¹ · kg⁻¹; P = 0.003) and insulin sensitivity, expressed as M/I ratio (M value divided by mean serum insulin at steady state: 3.73 ± 0.23 vs. 3.21 ± 0.27; P = 0.02), after fiber consumption were more pronounced. Plasma lipids, serum magnesium, ghrelin, and adiponectin concentrations, as well as substrate utilization and body weight, were not significantly changed by fiber intake (P > 0.15). CONCLUSIONS:--Increased insoluble dietary fiber intake for 3 days significantly improved whole-body insulin sensitivity. These data suggest a potential mechanism linking cereal fiber intake and reduced risk of type 2 diabetes.

• Publisher: American Diabetes Association
• Subject: adiponectin / administration & dosage / Avena / Biological and medical sciences / Blood Glucose / Blood Glucose - metabolism / blood lipids / blood serum / bran / Breath Tests / Cardiovascular disease / Cross-Over Studies / Diabetes / Diabetes Mellitus, Type 2 / Diabetes Mellitus, Type 2 - prevention & control / Diabetes. Impaired glucose tolerance / Diet therapy / Dietary fiber / Dietary Fiber - administration & dosage / Dietary Fiber - metabolism / Drug resistance / Endocrine pancreas. Apud cells (diseases) / Endocrinopathies / energy intake / Female / Fiber in human nutrition / ghrelin / glucose / Glucose - metabolism / Grain / Health aspects / Humans / Hydrogen / Hydrogen - metabolism / Hyperinsulinism / Hyperinsulinism - prevention & control / Hypoglycemic Agents / Hypoglycemic Agents - administration & dosage / Hypoglycemic Agents - metabolism / insoluble fiber / Insulin / Insulin - administration & dosage / Insulin - metabolism / Insulin Resistance / magnesium / Medical sciences / Metabolic diseases / metabolism / Middle Aged / noninsulin-dependent diabetes mellitus / Nutritional aspects / oats / Obesity / overweight / Overweight - physiology / physiology / prevention & control / risk / Risk factors / Single-Blind Method / Type 2 diabetes / white bread / Women