Asset Details
Do you wish to reserve the book?
Dual‐specificity phosphatase 8: A gatekeeper in hypothalamic control of glucose metabolism in males
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Dual‐specificity phosphatase 8: A gatekeeper in hypothalamic control of glucose metabolism in males
Do you wish to request the book?
Dual‐specificity phosphatase 8: A gatekeeper in hypothalamic control of glucose metabolism in males
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Dual‐specificity phosphatase 8: A gatekeeper in hypothalamic control of glucose metabolism in males
2021
Overview
Based on these results, the authors hypothesized that DUSP8-JNK signaling in the hypothalamus, including CRH-producing neurons, affects HPA axis reactivity involving the GR phosphorylation level, thereby modulating systemic glucose tolerance in male mice (Figure 1). [...]this line of research provides a novel insight into the role of the hypothalamus in systemic glucose metabolism. [...]it is not clear whether DUSP8 polymorphism affects its expression level and/or phosphatase activity. [...]why the effects of DUSP8 on insulin sensitivity in both humans and mice are present only in males remains to be elucidated. [...]although a meta-analysis showed that the association of DUSP8 single-nucleotide polymorphism re2334499 with type 2 diabetes was limited to males 2, a genome-wide association study, initially identifying DUSP8 as a type 2 diabetes risk gene, showed that the type 2 diabetes risk associated with re2334499 was inherited with the paternal allele 5. [...]details of the complexity of the association between type 2 diabetes susceptibility and DUSP8 polymorphism await future research.
Publisher
Wiley,John Wiley & Sons, Inc,John Wiley and Sons Inc
Subject
/ Diabetes
/ Diabetes mellitus (non-insulin dependent)
/ Diseases of the endocrine glands. Clinical endocrinology
/ Dual-Specificity Phosphatases
/ Dual-Specificity Phosphatases - metabolism
/ Genome-wide association studies
/ Genomes
/ Glucose
/ Humans
/ Hypothalamic-pituitary-adrenal axis
/ Insulin
/ Kinases
/ Male
/ Males
/ Obesity
/ Peptides
/ Rodents
/ Roles
