Asset Details
Do you wish to reserve the book?
Lack of effect of sublingual salvinorin A, a naturally occurring kappa opioid, in humans: a placebo-controlled trial
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Lack of effect of sublingual salvinorin A, a naturally occurring kappa opioid, in humans: a placebo-controlled trial
Do you wish to request the book?
Lack of effect of sublingual salvinorin A, a naturally occurring kappa opioid, in humans: a placebo-controlled trial
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Lack of effect of sublingual salvinorin A, a naturally occurring kappa opioid, in humans: a placebo-controlled trial
2011
Overview
Rationale
Salvinorin A (SA) is a highly selective kappa opioid receptor agonist and the putative psychoactive compound in
Salvia divinorum
(SD), an increasingly abused hallucinogenic plant.
Objectives
The objectives of this study were to characterize the physiological and subjective effects of SA versus placebo and measure drug and metabolite levels.
Methods
Sublingual SA doses up to 4 mg were administered in dimethyl sulfoxide/polyethylene glycol 400 solution to eight SD-experienced subjects using a placebo-controlled ascending-dose design.
Results
No dose of SA produced significantly greater physiological or subjective effects than placebo. Furthermore, effects did not resemble reported “typical” effects of smoked SD. SA was detectable in plasma and urine, but was, in most cases, below the reliable limit of quantification (0.5 ng/mL).
Conclusions
Our results suggest that the sublingual bioavailability of SA is low. Higher doses, alternate formulations, or alternate routes of administration will be necessary to study the effects of SA in humans.
Publisher
Springer-Verlag,Springer,Springer Nature B.V
Subject
/ Adult
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Diterpenes, Clerodane - administration & dosage
/ Diterpenes, Clerodane - isolation & purification
/ Diterpenes, Clerodane - pharmacokinetics
/ Diterpenes, Clerodane - pharmacology
/ Dose-Response Relationship, Drug
/ Female
/ Hallucinogens - administration & dosage
/ Hallucinogens - isolation & purification
/ Hallucinogens - pharmacokinetics
/ Hallucinogens - pharmacology
/ Heroin
/ Humans
/ Male
/ Receptors, Opioid, kappa - metabolism
/ Salvia
