Journal Article

Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis

Schmidt, Carl J., Lamont, Susan J., Jastrebski, Sara F.

2017

Overview

The liver plays a central role in metabolism and is important in maintaining homeostasis throughout the body. This study integrated transcriptomic and metabolomic data to understand how the liver responds under chronic heat stress. Chickens from a rapidly growing broiler line were heat stressed for 8 hours per day for one week and liver samples were collected at 28 days post hatch. Transcriptome analysis reveals changes in genes responsible for cell cycle regulation, DNA replication, and DNA repair along with immune function. Integrating the metabolome and transcriptome data highlighted multiple pathways affected by heat stress including glucose, amino acid, and lipid metabolism along with glutathione production and beta-oxidation.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Amino acids / Animals / Bioinformatics / Biology and Life Sciences / Body temperature / Cell cycle / Chickens / Cluster Analysis / Deoxyribonucleic acid / DNA / DNA biosynthesis / DNA Repair / DNA Replication / Fatty acids / Fatty Acids - metabolism / Gene expression / Gene Expression Profiling / Genetic aspects / Genomics / Glucose / Glutathione / Glutathione - metabolism / Heat / Heat shock proteins / Heat stress / Heat stress disorders / Heat Stress Disorders - metabolism / Heat tolerance / Heat-Shock Response - genetics / Homeostasis / Hot Temperature / Immune response / Immune System / Lipid Metabolism / Lipids / Liver / Liver - growth & development / Liver - metabolism / Male / Medicine and Health Sciences / Metabolism / Metabolites / Metabolome / Metabolomics / Nutrition / Oxidation / Oxidative stress / Oxygen - chemistry / Pathways / Physical Sciences / Physiological aspects / Physiology / Poultry / Risk factors / Transcriptome