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Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide
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Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide
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Journal Article
Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide
2015
Overview
Pyrrole-imidazole (Py-Im) polyamides are high affinity DNA-binding small molecules that can inhibit protein-DNA interactions. In VCaP cells, a human prostate cancer cell line overexpressing both AR and the TMPRSS2-ERG gene fusion, an androgen response element (ARE)-targeted Py-Im polyamide significantly downregulates AR driven gene expression. Polyamide exposure to VCaP cells reduced proliferation without causing DNA damage. Py-Im polyamide treatment also reduced tumor growth in a VCaP mouse xenograft model. In addition to the effects on AR regulated transcription, RNA-seq analysis revealed inhibition of topoisomerase-DNA binding as a potential mechanism that contributes to the antitumor effects of polyamides in cell culture and in xenografts. These studies support the therapeutic potential of Py-Im polyamides to target multiple aspects of transcriptional regulation in prostate cancers without genotoxic stress.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Animals
/ Antineoplastic Agents - chemistry
/ Antineoplastic Agents - therapeutic use
/ Antineoplastic Agents - toxicity
/ Binding
/ Cell Proliferation - drug effects
/ DNA
/ DNA Topoisomerases - chemistry
/ DNA Topoisomerases - metabolism
/ ERG gene
/ Gene Expression Regulation - drug effects
/ Humans
/ Male
/ Mice
/ Oncogene Proteins, Fusion - metabolism
/ Prostatic Neoplasms - drug therapy
/ Prostatic Neoplasms - metabolism
/ Prostatic Neoplasms - pathology
/ Receptors, Androgen - metabolism
/ RNA
/ Transplantation, Heterologous
/ Tumors
/ Urology
