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Chapter 11: Genome-Wide Association Studies
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Chapter 11: Genome-Wide Association Studies
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Journal Article
Chapter 11: Genome-Wide Association Studies
2012
Overview
Genome-wide association studies (GWAS) have evolved over the last ten years into a powerful tool for investigating the genetic architecture of human disease. In this work, we review the key concepts underlying GWAS, including the architecture of common diseases, the structure of common human genetic variation, technologies for capturing genetic information, study designs, and the statistical methods used for data analysis. We also look forward to the future beyond GWAS.
