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Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
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Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
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Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
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Journal Article
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
2015
Overview
YAP/TAZ are nuclear effectors of the Hippo pathway regulating organ growth and tumorigenesis. Yet, their function as transcriptional regulators remains underinvestigated. By ChIP-seq analyses in breast cancer cells, we discovered that the YAP/TAZ transcriptional response is pervasively mediated by a dual element: TEAD factors, through which YAP/TAZ bind to DNA, co-occupying chromatin with activator protein-1 (AP-1, dimer of JUN and FOS proteins) at composite
cis
-regulatory elements harbouring both TEAD and AP-1 motifs. YAP/TAZ/TEAD and AP-1 form a complex that synergistically activates target genes directly involved in the control of S-phase entry and mitosis. This control occurs almost exclusively from distal enhancers that contact target promoters through chromatin looping. YAP/TAZ-induced oncogenic growth is strongly enhanced by gain of AP-1 and severely blunted by its loss. Conversely, AP-1-promoted skin tumorigenesis is prevented in YAP/TAZ conditional knockout mice. This work highlights a new layer of signalling integration, feeding on YAP/TAZ function at the chromatin level.
Piccolo and colleagues report that the YAP/TAZ factors form ternary complexes with TEAD and AP-1 factors to drive a transcriptional program that promotes cell proliferation and tumour growth.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 45/61
/ 631/67
/ Adaptor Proteins, Signal Transducing - physiology
/ Animals
/ Cellular signal transduction
/ DNA-Binding Proteins - physiology
/ Female
/ Gene Expression Regulation, Neoplastic
/ Genome-Wide Association Study
/ Humans
/ Male
/ Nuclear Proteins - physiology
/ Phosphoproteins - physiology
/ resource
/ TEA Domain Transcription Factors
/ Transcription Factor AP-1 - genetics
