Journal Article

Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4

Hu, Zhibin, Na, Rong, Shao, Qiang, He, Dalin, Zheng, Ying, Shen, Mo, Jiao, Yang, Zhu, Yao, Long, Jirong, Zhang, Xuejun, Sun, Jishan, Wang, Gongxian, Liu, Fang, Dong, Pei, Rao, Jianyu, Ren, Shancheng, Gong, Jian, Yuan, Jianlin, Ye, Dingwei, Tao, Zhihua, Yao, Haijun, Ou-Yang, Jun, Zhang, Zhengdong, Chen, Hongyan, Qi, Jun, Xiang, Yongbing, Wei, Qiang, Hsing, Ann, Wang, Zhong, Wu, Denglong, Dai, Bo, Peng, Peng, Feng, Junjie, Chen, Zhiwen, Lin, Xiaoling, Shi, Rong, Zheng, S Lilly, Shen, Hongbing, Yu, Hongjie, Tao, Sha, Liu, Wennuan, Shu, Xiao-Ou, Zheng, Wei, Gao, Xu, Xu, Jianfeng, Zheng, Xiaodong, Guo, Jianming, Jin, Li, Sun, Jielin, Fu, Yaowen, Gao, Xin, Xu, Yong, Ding, Qiang, Zhou, Fangjian, Wu, Qijun, Sun, Yinghao, Jiang, Haowen, Wang, Meilin, Wang, Guozeng, Gronberg, Henrik, Xu, Chuanliang, Wang, Xiang, Yang, Yajun, Wiklund, Fredirik, Mo, Zengnan, Jin, Guangfu, Yang, Jin, Yin, Changjun, Lu, Daru

2012

Overview

Yinghao Sun and colleagues report a genome-wide association study for prostate cancer in Han Chinese men. They identify two new risk-associated loci at chromosomes 9q31 and 19q13. Prostate cancer risk–associated variants have been reported in populations of European descent, African-Americans and Japanese using genome-wide association studies (GWAS). To systematically investigate prostate cancer risk–associated variants in Chinese men, we performed the first GWAS in Han Chinese. In addition to confirming several associations reported in other ancestry groups, this study identified two new risk-associated loci for prostate cancer on chromosomes 9q31.2 (rs817826, P = 5.45 × 10 −14 ) and 19q13.4 (rs103294, P = 5.34 × 10 −16 ) in 4,484 prostate cancer cases and 8,934 controls. The rs103294 marker at 19q13.4 is in strong linkage equilibrium with a 6.7-kb germline deletion that removes the first six of seven exons in LILRA3 , a gene regulating inflammatory response, and was significantly associated with the mRNA expression of LILRA3 in T cells ( P < 1 × 10 −4 ). These findings may advance the understanding of genetic susceptibility to prostate cancer.

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: 631/208/205/2138 / 631/208/727/2000 / 631/67/2324 / 692/699/67/589/466 / Agriculture / Animal Genetics and Genomics / Asian Continental Ancestry Group / Bioinformatics / Biological and medical sciences / Biomedicine / Cancer Research / Chromosomes / Chromosomes, Human, Pair 19 / Chromosomes, Human, Pair 9 / Confidence intervals / DNA Repair Enzymes - genetics / DNA-Binding Proteins - genetics / Fundamental and applied biological sciences. Psychology / Gene Deletion / Gene Function / Genes / Genetic aspects / Genetic Predisposition to Disease / Genetics of eukaryotes. Biological and molecular evolution / Genome-Wide Association Study / Genomes / Gynecology. Andrology. Obstetrics / Health risks / Human Genetics / Humans / Kruppel-Like Transcription Factors - genetics / letter / Male / Male genital diseases / Medical sciences / Men / Methods / Mortality / Nephrology. Urinary tract diseases / Physiological aspects / Polymorphism, Single Nucleotide / Prostate cancer / Prostatic Neoplasms - genetics / Receptors, Immunologic - genetics / Risk Factors / Single nucleotide polymorphisms / Software / Tumors / Tumors of the urinary system / Urinary tract. Prostate gland