Journal Article

Associations of Gestational Perfluoroalkyl Substances Exposure with Early Childhood BMI z-Scores and Risk of Overweight/Obesity: Results from the ECHO Cohorts

O’Connor, Thomas G., Dabelea, Dana, Schantz, Susan, Dunlop, Anne L., Oken, Emily, Hamra, Ghassan B., Chatzi, Leda, Starling, Anne P., Romano, Megan E., Liu, Yun, Braun, Joseph M., Woodruff, Tracey J., Ferrara, Assiamira, Zhu, Yeyi, Fleisch, Abby F., Buckley, Jessie P., Wosu, Adaeze C., Karagas, Margaret R.

2023

Overview

Gestational per- and polyfluoroalkyl substances (PFAS) exposure may be associated with adiposity and increased risk of obesity among children and adolescents. However, results from epidemiological studies evaluating these associations are inconsistent. We estimated the associations of pregnancy PFAS concentrations with child body mass index (BMI) -scores and risk of overweight/obesity in eight U.S. cohorts. We used data from 1,391 mother-child pairs who enrolled in eight Environmental influences on Child Health Outcomes (ECHO) cohorts (enrolled: 1999-2019). We quantified concentrations of seven PFAS in maternal plasma or serum in pregnancy. We measured child weight and height between the ages of 2 and 5 y and calculated age- and sex-specific BMI -scores; 19.6% children had more than one BMI measurement. We estimated covariate-adjusted associations of individual PFAS and their mixture with child BMI -scores and risk of overweight/obesity using linear mixed models, modified Poisson regression models, and Bayesian approaches for mixtures. We explored whether child sex modified these associations. We observed a pattern of subtle positive associations of PFAS concentrations in pregnancy with BMI -scores and risk of overweight/obesity. For instance, each doubling in perfluorohexane sulfonic acid concentrations was associated with higher BMI -scores ( ; 95% CI: 0.01, 0.12). Each doubling in perfluroundecanoic acid [ ; 95% CI: 1.04, 1.16] and -methyl perfluorooctane sulfonamido acetic acid ( ; 95% CI: 1.00, 1.12) was associated with increased risk of overweight/obesity, with some evidence of a monotonic dose-response relation. We observed weaker and more imprecise associations of the PFAS mixture with BMI or risk of overweight/obesity. Associations did not differ by child sex. In eight U.S.-based prospective cohorts, gestational exposure to higher levels of PFAS were associated with slightly higher childhood BMI -score and risk of overweight or obesity. Future studies should examine associations of gestational exposure to PFAS with adiposity and related cardiometabolic consequences in older children. https://doi.org/10.1289/EHP11545.

• Publisher: National Institute of Environmental Health Sciences,Environmental Health Perspectives
• Subject: Acetic acid / Adipose tissue / Adolescent / Alkanesulfonic Acids / Bayes Theorem / Bayesian analysis / Body height / Body Mass Index / Body size / Body weight / Child / Child, Preschool / Children / Environmental aspects / Environmental Pollutants / Epidemiology / Exposure / Female / Fluorocarbons / Health aspects / Humans / Male / Mathematical models / Mixtures / Mother-offspring interactions / Obesity / Obesity - chemically induced / Obesity in children / Overweight / Overweight - chemically induced / Overweight - complications / Overweight - epidemiology / Pediatric research / Perfluoro compounds / Perfluoroalkyl & polyfluoroalkyl substances / Perfluorochemicals / Perfluorohexane / Pregnancy / Prenatal exposure / Prenatal influences / Prospective Studies / Regression analysis / Regression models / Risk / Risk factors / Sex / Sulfonic acid / Teenagers