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Comparison of the SARS-CoV-2 spike protein ELISA and the Abbott Architect SARS-CoV-2 IgG nucleocapsid protein assays for detection of antibodies

by Killerby, Marie , Pomeroy, Mary , Hall, Patricia , Kirking, Hannah L. , Wadhwa, Ashutosh , Hershow, Rebecca B. , Freeman, Brandi , Bhattacharyya, Sanjib , Yin, Sherry , Yousaf, Anna R. , Tate, Jacqueline E. , Mills, Lisa , Buono, Sean A. , Lester, Sandra , Chu, Victoria T. , Owusu, Daniel , Thornburg, Natalie J.

in Analysis / Antibodies / Antigens / Architects / Assaying / Biology and life sciences / Comparative analysis / Coronaviruses / COVID-19 / COVID-19 diagnostic tests / COVID-19 vaccines / Disease transmission / Enrollments / Enzyme-linked immunosorbent assay / Households / Immunization / Immunoassay / Immunoglobulin G / Medical laboratories / Medicine and Health Sciences / Nucleocapsids / Proteins / Public health / Research and Analysis Methods / Serology / Severe acute respiratory syndrome / Severe acute respiratory syndrome coronavirus 2 / Spike protein / Supervision / Viral antibodies

2021

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Comparison of the SARS-CoV-2 spike protein ELISA and the Abbott Architect SARS-CoV-2 IgG nucleocapsid protein assays for detection of antibodies

2021

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Comparison of the SARS-CoV-2 spike protein ELISA and the Abbott Architect SARS-CoV-2 IgG nucleocapsid protein assays for detection of antibodies

2021

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Journal Article

Comparison of the SARS-CoV-2 spike protein ELISA and the Abbott Architect SARS-CoV-2 IgG nucleocapsid protein assays for detection of antibodies

Killerby, Marie,

Pomeroy, Mary,

Hall, Patricia,

Kirking, Hannah L.,

Wadhwa, Ashutosh,

Hershow, Rebecca B.,

Freeman, Brandi,

Bhattacharyya, Sanjib,

Yin, Sherry,

Yousaf, Anna R.,

Tate, Jacqueline E.,

Mills, Lisa,

Buono, Sean A.,

Lester, Sandra,

Chu, Victoria T.,

Owusu, Daniel,

Thornburg, Natalie J.

2021

Overview

Serologic assays developed for SARS-CoV-2 detect different antibody subtypes and are based on different target antigens. Comparison of the performance of a SARS-CoV-2 Spike-Protein ELISA and the nucleocapsid-based Abbott Architect TM SARS-CoV-2 IgG assay indicated that the assays had high concordance, with rare paired discordant tests results.

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

/ Biology and life sciences

/ Comparative analysis