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Polyphosphate and Its Diverse Functions in Host Cells and Pathogens
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Polyphosphate and Its Diverse Functions in Host Cells and Pathogens
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Journal Article
Polyphosphate and Its Diverse Functions in Host Cells and Pathogens
2013
Overview
Actin inhibitors such as phalloidin and DNase I also inhibit DdPPK2-mediated synthesis of polyP. [...]this particular actin-related protein complex is an enzyme that can polymerize into an actin-like filament concurrent with its synthesis of a polyP chain in a fully reversible reaction [15].\\n It was also shown that polyPs have a potent modulatory activity on blood coagulation [24] and inflammation [25]. Role of PolyP in Pathogenesis PolyP, which in bacteria is mainly of long-chain type (>300 and up to 1,000 Pi residues), has been reported to be important for virulence of different bacteria, such as Salmonella spp., Shigella flexneri, Vibrio cholerae, Neisseria meningitides, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, but the mechanism involved is not known [30].
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
