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Diagnostic potential of genomic blood biomarkers of pulmonary fibrosis in a prospective cohort
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Diagnostic potential of genomic blood biomarkers of pulmonary fibrosis in a prospective cohort
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Diagnostic potential of genomic blood biomarkers of pulmonary fibrosis in a prospective cohort
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Journal Article
Diagnostic potential of genomic blood biomarkers of pulmonary fibrosis in a prospective cohort
2024
Overview
Fibrotic interstitial lung diseases (ILDs) result from excessive deposition of extracellular matrix (ECM) proteins in the lung, causing irreversible damage to the lung architecture. Clinical management of ILDs differs depending on the diagnosis, but differentiation between subtypes can be difficult and better clinical biomarkers are needed. In this study, we use a 166-gene NanoString assay to investigate whether there are ILD subtype-specific transcripts in whole blood. We identified one transcript, killer cell lectin like receptor 1 ( KLRF1 ), as differentially expressed between idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated ILD (SSc-ILD), and identified two transcripts ( VCAN , LTK ) associated with IPF expression against other ILD subtypes. These findings were validated by examining their expression in ILD lung, with KLRF1 expression significantly higher in SSc-ILD compared to IPF and hypersensitivity pneumonitis (HP) samples. Taken together, this pilot study provides support for the use of the peripheral transcriptome in identifying diagnostic biomarkers of ILD with biological relevance.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Alveolitis, Extrinsic Allergic - blood
/ Alveolitis, Extrinsic Allergic - diagnosis
/ Alveolitis, Extrinsic Allergic - genetics
/ Analysis
/ Blood
/ Female
/ Fibrosis
/ Humans
/ Idiopathic Pulmonary Fibrosis - blood
/ Idiopathic Pulmonary Fibrosis - diagnosis
/ Idiopathic Pulmonary Fibrosis - genetics
/ Lung Diseases, Interstitial - blood
/ Lung Diseases, Interstitial - diagnosis
/ Lung Diseases, Interstitial - genetics
/ Male
/ Medicine and Health Sciences
/ Pulmonary Fibrosis - diagnosis
/ Pulmonary Fibrosis - genetics
/ Scleroderma, Systemic - blood
/ Scleroderma, Systemic - complications
/ Scleroderma, Systemic - diagnosis
