Journal Article

Elective one-minute full brain multi-contrast MRI versus brain CT in pediatric patients: a prospective feasibility study

Kvist, Ola, Österman, Yords, Diaz Ruiz, Sandra, De Luca, Francesca, Martin Muñoz, Daniel, Skare, Stefan, Kits, Annika, Aspelin, Åsa, Falk Delgado, Anna

2024

Overview

Background Brain CT can be used to evaluate pediatric patients with suspicion of cerebral pathology when anesthetic and MRI resources are scarce. This study aimed to assess if pediatric patients referred for an elective brain CT could endure a diagnostic fast brain MRI without general anesthesia using a one-minute multi-contrast EPI-based sequence (EPIMix) with comparable diagnostic performance. Methods Pediatric patients referred for an elective brain CT between March 2019 and March 2020 were prospectively included and underwent EPIMix without general anesthesia in addition to CT. Three readers (R1–3) independently evaluated EPIMix and CT images on two separate occasions. The two main study outcomes were the tolerance to undergo an EPIMix scan without general anesthesia and its performance to classify a scan as normal or abnormal. Secondary outcomes were assessment of disease category, incidental findings, diagnostic image quality, diagnostic confidence, and image artifacts. Further, a side-by-side evaluation of EPIMix and CT was performed. The signal-to-noise ratio (SNR) was calculated for EPIMix on T1-weighted, T2-weighted, and ADC images. Descriptive statistics, Fisher’s exact test, and Chi-squared test were used to compare the two imaging modalities. Results EPIMix was well tolerated by all included patients ( n  = 15) aged 5–16 (mean 11, SD 3) years old. Thirteen cases on EPIMix and twelve cases on CT were classified as normal by all readers (R1–3), while two cases on EPIMix and three cases on CT were classified as abnormal by one reader (R1), (R1–3, p  = 1.00). There was no evidence of a difference in diagnostic confidence, image quality, or the presence of motion artifacts between EPIMix and CT (R1–3, p  ≥ 0.10). Side-by-side evaluation (R2 + R4 + R5) reviewed all scans as lacking significant pathological findings on EPIMix and CT images. Conclusions Full brain MRI-based EPIMix sequence was well tolerated without general anesthesia with a diagnostic performance comparable to CT in elective pediatric patients. Trial registration This study was approved by the Swedish Ethical Review Authority (ethical approval number/ID Ethical approval 2017/2424-31/1). This study was a clinical trial study, with study protocol published at ClinicalTrials.gov with Trial registration number NCT03847051, date of registration 18/02/2019.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Anesthesia / Brain / Brain - diagnostic imaging / Brain research / Chi-square test / Child / Child, Preschool / Children / Classification / Clinical Medicine / Computed tomography / Confidence / CT imaging / Cysts / Diagnostic systems / Endocrine system / EPIMix / Ethical standards / Ethics / Fast and high-resolution medical imaging / Fast brain MRI / Feasibility Studies / General anesthesia / Health aspects / Humans / Image quality / Imaging / Klinisk medicin / Likert scale / Magnetic Resonance Imaging / Medical and Health Sciences / Medical imaging / Medical research / Medicin och hälsovetenskap / Medicine / Medicine & Public Health / Medicine, Experimental / Neuroimaging / Pathology / Patients / Pediatric brain CT / Pediatric brain MRI / Pediatrics / Prospective Studies / Radiation / Radiologi och bildbehandling / Radiology / Radiology and Medical Imaging / Signal to noise ratio / Statistical analysis / Tomography, X-Ray Computed