Journal Article

Cross-linking for microbial keratitis

Vazirani, Jayesh, Vaddavalli, Pravin

2013

Overview

The success of collagen cross-linking as a clinical modality to modify the clinical course in keratoconus seems to have fueled the search for alternative applications for this treatment. Current clinical data on its efficacy is limited and laboratory data seems to indicate that it performs poorly against resistant strains of bacteria and against slow growing organisms. However, the biological plausibility of crosslinking and the lack of effective strategies in managing infections with these organisms continue to focus attention on this potential treatment. Well-conducted experimental and clinical studies with controls are required to answer the questions of its efficacy in future.

• Publisher: Medknow Publications,Medknow Publications and Media Pvt. Ltd,Medknow Publications & Media Pvt. Ltd,Medknow Publications & Media Pvt Ltd,Wolters Kluwer Medknow Publications
• Subject: acanth / Accelerated corneal cross linking / Care and treatment / Collagen - metabolism / Collagen cross linking / Contact lens / Cornea / Cornea collagen cross linking / Corneal collagen cross linking / Corneal cross-linking / Corneal cross-linking techniques / corneal ectasia / corneal ectosia / corneal laser surgery / Corneal Stroma - metabolism / Corneal topography / corneal transplant / Cross-Linking Reagents - therapeutic use / crosslinking / Deregulation / Disease pathogenesis / Drug Resistance, Bacterial / ectasia / Ectatic disease / Epidemiology / Eye / Eye Infections, Bacterial - drug therapy / Eye Infections, Bacterial - metabolism / Eye Infections, Bacterial - microbiology / fungus / gene expression / genetic heterogeneity / genetics and genomics / genome-wide association study / genomic loci / Humans / hypoosmolar riboflavin / imaging / Keratitis - drug therapy / Keratitis - metabolism / Keratitis - microbiology / Keratoconus / Laser in situ keratomileusis surgery / LASIK ectosia prophylaxis / linkage mapping / long term results / mass spectroscopy / microbial keratitis / modulus / molecular mechanisms / new technologies / ocular allergy / optical coherence tomography / Patient outcomes / pediatric keratoconus / Photochemotherapy - methods / Photosensitizing Agents - therapeutic use / piggy back contact lenses / placido disc based topography / prevalence / proteomics / radiant exposure / riboflavin / Riboflavin - therapeutic use / rigid gas permeable / scheimpflug imaging / scleral lens / signaling pathways / Surgery / Symposium: Keratoconus / SynergEyes / thin cornea / toric soft contact lens / transepithelial collagen cross-linking / Ultraviolet Rays / ultraviolet-A / UV light / vernal keratoconjunctivitis / very high fluence collagen cross-linking / whole exome-genome sequencing