Journal Article

Genomic history of the origin and domestication of common bean unveils its closest sister species

Vlasova, Anna, Montero-Vargas, Josaphat M., Gabaldón, Toni, Herrera-Estrella, Alfredo, Capella-Gutierrez, Salvador, Ordaz-Ortiz, José Juan, Santalla, Marta, Vianello-Brondani, Rosana P., Gepts, Paul, Saburido-Álvarez, Soledad, Delgado-Salinas, Alfonso, Guigó, Roderic, Rendón-Anaya, Martha, Winkler, Robert, Aguilar, O. Mario, Delaye, Luis

2017

Overview

Background Modern civilization depends on only a few plant species for its nourishment. These crops were derived via several thousands of years of human selection that transformed wild ancestors into high-yielding domesticated descendants. Among cultivated plants, common bean ( Phaseolus vulgaris L . ) is the most important grain legume. Yet, our understanding of the origins and concurrent shaping of the genome of this crop plant is limited. Results We sequenced the genomes of 29 accessions representing 12 Phaseolus species. Single nucleotide polymorphism-based phylogenomic analyses, using both the nuclear and chloroplast genomes, allowed us to detect a speciation event, a finding further supported by metabolite profiling. In addition, we identified ~1200 protein coding genes (PCGs) and ~100 long non-coding RNAs with domestication-associated haplotypes. Finally, we describe asymmetric introgression events occurring among common bean subpopulations in Mesoamerica and across hemispheres. Conclusions We uncover an unpredicted speciation event in the tropical Andes that gave rise to a sibling species, formerly considered the “wild ancestor” of P. vulgaris , which diverged before the split of the Mesoamerican and Andean P. vulgaris gene pools. Further, we identify haplotypes strongly associated with genes underlying the emergence of domestication traits. Our findings also reveal the capacity of a predominantly autogamous plant to outcross and fix loci from different populations, even from distant species, which led to the acquisition by domesticated beans of adaptive traits from wild relatives. The occurrence of such adaptive introgressions should be exploited to accelerate breeding programs in the near future.

• Publisher: BioMed Central,Springer Nature B.V,BMC
• Subject: Adaptation / Adaptive traits / Andes region / Animal Genetics and Genomics / Beans / Bioinformatics / Biomedical and Life Sciences / breeding programs / Central America / chloroplast genome / Chloroplasts / Common bean / Corn / crops / Domestication / Evolution / Evolutionary Biology / Flavonoids - biosynthesis / Gene Flow / gene pool / genes / Genetic diversity / Genetic Variation / Genome, Plant / Genomes / Genomic introgression / Genomics / Haplotypes / Human Genetics / humans / introgression / Life Sciences / loci / Mass spectrometry / metabolites / Metabolome / Metabolomics - methods / Microbial Genetics and Genomics / non-coding RNA / nuclear genome / Phaseolus - classification / Phaseolus - genetics / Phaseolus - metabolism / Phaseolus vulgaris / Phylogenetics / Phylogeny / Plant Genetics and Genomics / Plant Physiological Phenomena - genetics / Scientific imaging / Selection, Genetic / Sibling species / Single-nucleotide polymorphism / Speciation / Species Specificity / Subpopulations / wild relatives