Journal Article

Influence of Clinical Parameters and Anticoagulation on Intraprocedural Cerebral Microembolic Signals during Pulmonary Vein Isolation

Korsukewitz, Catharina, Schmitges, Jan, Kochhaeuser, Simon, Guener, Fatih, Wasmer, Kristina, Moennig, Gerold, Pott, Christian, Kerckhoff, Monika, Eckardt, Lars, Dittrich, Ralf, Leitz, Patrick, Larbig, Robert, Dechering, Dirk

2016

Overview

We had the objective to determine the impact of clinical parameters and anticoagulation status on cerebral microembolic signals (MES) during pulmonary vein isolation (PVI) for atrial fibrillation (AF). Thromboembolism and stroke are the most feared complications of PVI. MES can help to evaluate embolic burden. It is unknown whether clinical parameters have an impact on embolic risk during PVI. In this retrospective analysis we investigated the impact of clinical parameters, including the CHADS2- and CHA2DS2-VASc-score, pulmonary vein variants and echocardiographic parameters on MES rates in patients that underwent PVI using three different ablation approaches (radiofrequency ablation (iRF), pulmonary vein ablation catheter (PVAC) with deactivated electrode pair 1 or 5 (PVAC-red) or PVAC without deactivation (PVAC-all). 118 AF patients (61±12 years) were included between 2011 and 2013 (Median: 489 MES during PVI). Patients were more likely to have more MES (within 4th quartile) with the PVAC-all approach (60.7% vs. 25.0% (iRF) vs. 14.3% (PVAC-red) respectively (p<0.001). Patients with oral anticoagulation (OAC) pre-ablation were more likely to have lower MES-counts (1st-3rd quartile); (65.6% vs. 35.7%; p = 0.005). Additionally, patients with lower MES counts (1st-3rd quartile) had significantly higher INR values than those in the 4th quartile (1.78 vs. 1.09; p = 0.029). 2 patients developed a potentially thromboembolic event during the procedure. Clinical predictors of cerebral emboli and stroke do not correlate with cerebral embolic burden during PVI. Pre-ablation OAC and increased INR values correlate with decreased MES-rates. Therefore, it might be beneficial to perform PVI with pre-ablation anticoagulation even in low risk patients.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Ablation / Ablation (Surgery) / Anticoagulants / Anticoagulants - therapeutic use / Atrial fibrillation / Biology and Life Sciences / Cardiac arrhythmia / Care and treatment / Catheters / Complications / Deactivation / Dosage and administration / Female / Fibrillation / Health aspects / Humans / International Normalized Ratio / Intracranial Embolism - drug therapy / Intracranial Embolism - surgery / Male / Medical imaging / Medical instruments / Medicine / Medicine and Health Sciences / Middle Aged / Parameters / Patient outcomes / Patients / Polyvinyl acetates / Prognosis / Pulmonary Veins - surgery / Radio frequency / Risk factors / Stroke / Thromboembolism / Tomography / Veins & arteries