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A microtubule-binding myosin required for nuclear anchoring and spindle assembly
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Journal Article
A microtubule-binding myosin required for nuclear anchoring and spindle assembly
2004
Overview
Proper spindle positioning and orientation are essential for asymmetric cell division and require microtubule–actin filament (F-actin) interactions in many systems
1
,
2
. Such interactions are particularly important in meiosis
3
, where they mediate nuclear anchoring
4
,
5
,
6
, as well as meiotic spindle assembly and rotation
7
,
8
, two processes required for asymmetric cell division. Myosin-10 proteins are phosphoinositide-binding
9
, actin-based motors that contain carboxy-terminal MyTH4 and FERM domains of unknown function
10
. Here we show that
Xenopus laevis
myosin-10 (Myo10) associates with microtubules
in vitro
and
in vivo
, and is concentrated at the point where the meiotic spindle contacts the F-actin-rich cortex. Microtubule association is mediated by the MyTH4-FERM domains, which bind directly to purified microtubules. Disruption of Myo10 function disrupts nuclear anchoring, spindle assembly and spindle–F-actin association. Thus, this myosin has a novel and critically important role during meiosis in integrating the F-actin and microtubule cytoskeletons.
Publisher
Nature Publishing Group UK,Nature Publishing,Nature Publishing Group
Subject
/ Animals
/ Biological and medical sciences
/ Cell cycle, cell proliferation
/ Fundamental and applied biological sciences. Psychology
/ Humanities and Social Sciences
/ letter
/ Molecular and cellular biology
/ Science
/ Spindle Apparatus - chemistry
/ Spindle Apparatus - metabolism
