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BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder
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BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder
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BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder
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Journal Article
BDNF protein levels are decreased in transformed lymphoblasts from lithium-responsive patients with bipolar disorder
2008
Overview
Objective Brain-derived neurotrophic factor (BDNF) is a key factor in neuroplasticity and has been implicated in the affective disorders; studies have demonstrated elevated BDNF in patients taking lithium and other mood stabilizers. The objective of our study was to analyze BDNF in lithium-responsive patients with bipolar disorder (BD) to further understand the role of BDNF in the pathophysiology of BD. Methods Using enzyme-linked immunosorbent assay, we measured transformed B lymphocytes for BDNF protein. Results BDNF levels were 36% lower in lymphoblasts from patients with BD ( n = 12), compared with matched control participants ( n = 13), and 55% lower when compared with their unaffected relatives ( n = 14). Lithium significantly decreased BDNF levels in patients with BD and healthy control participants, although BDNF levels remained lower (33%) in the BD group posttreatment. Conclusion Decreased BDNF may constitute part of the pathophysiologic process of BD in a lithium-responsive subgroup of individuals with this disease. A compensatory mechanism protecting the genetically predisposed unaffected relatives from phenotypic expression of BD is suggested.
Publisher
Canadian Medical Association,NRC Research Press,CMA Impact Inc,Cooperative Education Association
Subject
/ Adult and adolescent clinical studies
/ Antimanic Agents - therapeutic use
/ Biological and medical sciences
/ Bipolar Disorder - drug therapy
/ Bipolar Disorder - physiopathology
/ Brain-derived neurotrophic factor
/ Brain-Derived Neurotrophic Factor - blood
/ Brain-Derived Neurotrophic Factor - genetics
/ Enzyme-Linked Immunosorbent Assay
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Lithium
/ Lithium Carbonate - therapeutic use
/ Lymphocyte Activation - physiology
/ Male
/ Proteins
/ Psychology. Psychoanalysis. Psychiatry
