Journal Article

Maternal vitamin D status in relation to cardiometabolic risk factors in children from the Norwegian Environmental Biobank

Bärebring, Linnea, Amberntsson, Anna, Winkvist, Anna, Erlund, Iris, Papadopoulou, Eleni, Lissner, Lauren, Brantsæter, Anne Lise, Augustin, Hanna

2025

Overview

Maternal 25-hydroxyvitamin D (25OHD) status has been associated with birth weight and childhood growth. Further, maternal 25OHD status may also influence cardiometabolic outcomes in childhood. This study investigated the association between maternal 25OHD concentration in pregnancy and markers of cardiometabolic risk in 7-12-year-old children. Data were obtained from the Norwegian Environmental Biobank (NEB) including 244 mother-child pairs in the Norwegian Mother, Father and Child Cohort Study (MoBa) participating in NEB part I and II. Childhood outcomes investigated were z-scores of anthropometrics, blood lipids and hormones. Associations between maternal 25OHD and individual cardiometabolic risk factors in children were assessed by linear regression, adjusted for maternal pre-pregnancy BMI, maternal education, child's sex, age and BMI, and tested for interaction with pre-pregnancy BMI. Per 10 nmol/L increase in maternal 25OHD, childhood adiponectin z-score increased by 0.067 standard deviations (p = 0.039). There were no associations between maternal 25OHD concentration and any other cardiometabolic risk factor in childhood. The results indicate that higher maternal vitamin D status during pregnancy may be related to higher childhood adiponectin z-score, but not with any other cardiometabolic risk marker. Whether adiponectin could be one pathway linking vitamin D to cardiometabolic health remains to be determined.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: 25-Hydroxyvitamin D / Adiponectin / Adiponectin - blood / Adult / Alfacalcidol / Biological Specimen Banks / Biology and Life Sciences / Birth weight / Body Mass Index / Calcifediol / Calciferol / Cardiometabolic Risk Factors / Cardiovascular diseases / Cardiovascular Diseases - blood / Care and treatment / Child / Children / Clinical outcomes / Cohort Studies / Female / Genetic aspects / Gynaecology, Obstetrics and Reproductive Medicine / Gynekologi, obstetrik och reproduktionsmedicin / Health aspects / Health risks / High density lipoprotein / Hormones / Humans / Laboratories / Lipids / Male / Measurement / Medicine and Health Sciences / Metabolic diseases / Mother-offspring interactions / Norway - epidemiology / Obesity / Patient outcomes / People and Places / Physical sciences / Pregnancy / Risk Factors / Social aspects / Vitamin D / Vitamin D - analogs & derivatives / Vitamin D - blood / Womens health