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In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect

by Lakhal, Marwa , Ben Mustapha, Imen , Ghedira, Kais , Kharrat, Maher , Touati, Rabeb , Ayouni, Kaouther , Othman, Houcemeddine , Triki, Henda , Haddad-Boubaker, Sondes

in Algorithms / Amino acids / Antibodies / Antigenicity / Antigens / Antigens, Viral / Antigens, Viral - immunology / Attenuated vaccines / Bacterial vaccines / BCG / BCG Vaccine / Bioinformatics / Biomedical and Life Sciences / Comparative analysis / Comparative studies / Computational Biology/Bioinformatics / Computer Appl. in Life Sciences / Computer Simulation / Coronaviruses / COVID-19 / COVID-19 Vaccines / Cross Protection / Disease transmission / Fatalities / Genetic aspects / Health aspects / Hepatitis B / Humans / Immune response / Immunogenicity / Life Sciences / Measles / Microarrays / MMR / Mumps / OPV / Pandemics / Pathogens / Peptides / Protein Conformation / Proteins / Public health / Research Article / Rubella / SARS-CoV-2 / SARS-CoV-2 - chemistry / Segments / Severe acute respiratory syndrome coronavirus 2 / Streptococcus infections / Testing / Tetanus / Vaccine / Vaccines / Viral diseases / Viral Proteins / Viral Proteins - immunology / Viral Vaccines / Viral Vaccines - immunology

2021

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In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect

by Lakhal, Marwa , Ben Mustapha, Imen , Ghedira, Kais , Kharrat, Maher , Touati, Rabeb , Ayouni, Kaouther , Othman, Houcemeddine , Triki, Henda , Haddad-Boubaker, Sondes

2021

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In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect

by Lakhal, Marwa , Ben Mustapha, Imen , Ghedira, Kais , Kharrat, Maher , Touati, Rabeb , Ayouni, Kaouther , Othman, Houcemeddine , Triki, Henda , Haddad-Boubaker, Sondes

2021

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Journal Article

In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effect

Lakhal, Marwa,

Ben Mustapha, Imen,

Ghedira, Kais,

Kharrat, Maher,

Touati, Rabeb,

Ayouni, Kaouther,

Othman, Houcemeddine,

Triki, Henda,

Haddad-Boubaker, Sondes

2021

Overview

Background Coronavirus Disease 2019 (COVID-19) is a viral pandemic disease that may induce severe pneumonia in humans. In this paper, we investigated the putative implication of 12 vaccines, including BCG, OPV and MMR in the protection against COVID-19. Sequences of the main antigenic proteins in the investigated vaccines and SARS-CoV-2 proteins were compared to identify similar patterns. The immunogenic effect of identified segments was, then, assessed using a combination of structural and antigenicity prediction tools. Results A total of 14 highly similar segments were identified in the investigated vaccines. Structural and antigenicity prediction analysis showed that, among the identified patterns, three segments in Hepatitis B, Tetanus, and Measles proteins presented antigenic properties that can induce putative protective effect against COVID-19. Conclusions Our results suggest a possible protective effect of HBV, Tetanus and Measles vaccines against COVID-19, which may explain the variation of the disease severity among regions.

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Publisher

BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC

Subject

/ Antigens, Viral - immunology