Journal Article

cnm-positive Streptococcus mutans is associated with galactose-deficient IgA in patients with IgA nephropathy

Lee, Mingfeng, Aoki, Ryosuke, Nomura, Ryota, Nagasawa, Yasuyuki, Ito, Seigo, Matsuoka, Daiki, Misaki, Taro, Suzuki, Yusuke, Nakano, Kazuhiko, Suzuki, Hitoshi, Matsumoto-Nakano, Michiyo, Naka, Shuhei

2023

Overview

The presence of Streptococcus mutans expressing Cnm protein encoded by cnm ( cnm -positive S . mutans ) in the oral cavity is associated with immunoglobulin A (IgA) nephropathy (IgAN). However, the precise mechanism by which cnm -positive S . mutans is involved in the pathogenesis of IgAN remains unclear. The present study evaluated glomerular galactose-deficient IgA1 (Gd-IgA1) to clarify the association between the presence of cnm -positive S . mutans and glomerular Gd-IgA1 in patients with IgAN. The presence of S . mutans and cnm -positive S . mutans was evaluated by polymerase chain reaction in saliva specimens from 74 patients with IgAN or IgA vasculitis. Immunofluorescent staining of IgA and Gd-IgA1 using KM55 antibody in clinical glomerular tissues was then performed. There was no significant association between the glomerular staining intensity of IgA and the positive rate of S . mutans . However, there was a significant association between the glomerular staining intensity of IgA and the positive rate of cnm -positive S . mutans ( P < 0.05). There was also a significant association between the glomerular staining intensity of Gd-IgA1 (KM55) and the positive rate of cnm -positive S . mutans ( P < 0.05). The glomerular staining intensity of Gd-IgA1 (KM55) was not associated with the positive rate of S . mutans . These results suggest that cnm -positive S . mutans in the oral cavity is associated with the pathogenesis of Gd-IgA1 in patients with IgAN.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Antibodies / Bacterial infections / Biology and Life Sciences / Biopsy / Complications and side effects / Creatinine / Dental caries / Development and progression / Enzymes / Gadolinium / Galactose / Genetic aspects / Glomerulonephritis, IGA / Humans / Identification and classification / IgA glomerulonephritis / IgA nephropathy / Immunoglobulin A / Infections / Laboratories / Medicine and Health Sciences / Monoclonal antibodies / Oral cavity / Pathogenesis / Pathogens / Physiological aspects / Plasma / Polymerase chain reaction / Proteins / Regression analysis / Research and Analysis Methods / Risk factors / Saliva / Staining / Statistical analysis / Streptococcal infections / Streptococcus infections / Streptococcus mutans / Vasculitis