Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

The Cancer Stem Cell Marker CD133 Interacts with Plakoglobin and Controls Desmoglein-2 Protein Levels

by Hoshino-Okubo, Akemi , Okamoto, Aikou , Yanaihara, Nozomu , Takahashi, Rina , Manabe, Emi , Oyama, Masaaki , Kozuka-Hata, Hiroko , Yanagida, Satoshi , Haruta, Ryo , Tanaka, Tadao , Akiyama, Tetsu , Koyama-Nasu, Ryo , Nasu-Nishimura, Yukiko , Omi, Hiroko

in AC133 Antigen / Animals / Antigens, CD - metabolism / Biology / Biomarkers, Tumor - metabolism / Caco-2 Cells / Cadherins / Cancer / Catenin / Cell Adhesion / Cell adhesion & migration / Cell Transformation, Neoplastic - metabolism / Cell Transformation, Neoplastic - pathology / Chemotherapy / Desmoglein 2 - metabolism / gamma Catenin - metabolism / Gene expression / Glycoproteins / Glycoproteins - metabolism / Gynecology / Humans / Laboratories / Mass spectrometry / Medicine / Membrane proteins / Mice / Neoplastic Stem Cells - metabolism / Neoplastic Stem Cells - pathology / Obstetrics / Ovarian cancer / Peptides - metabolism / Protein Binding / Proteins / Proteomics / Ribonucleic acid / RNA / RNA-mediated interference / Scientific imaging / Stem cell transplantation / Stem cells / Tumorigenicity / Tumors

2013

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

The Cancer Stem Cell Marker CD133 Interacts with Plakoglobin and Controls Desmoglein-2 Protein Levels

2013

Confirm

Do you wish to request the book?

The Cancer Stem Cell Marker CD133 Interacts with Plakoglobin and Controls Desmoglein-2 Protein Levels

2013

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

The Cancer Stem Cell Marker CD133 Interacts with Plakoglobin and Controls Desmoglein-2 Protein Levels

Hoshino-Okubo, Akemi,

Okamoto, Aikou,

Yanaihara, Nozomu,

Takahashi, Rina,

Manabe, Emi,

Oyama, Masaaki,

Kozuka-Hata, Hiroko,

Yanagida, Satoshi,

Haruta, Ryo,

Tanaka, Tadao,

Akiyama, Tetsu,

Koyama-Nasu, Ryo,

Nasu-Nishimura, Yukiko,

Omi, Hiroko

2013

Overview

The pentaspan membrane glycoprotein CD133 (also known as prominin-1) has been widely used as a marker for both cancer and normal stem cells. However, the function of CD133 has not been elucidated. Here we describe a cancer stem cell line established from clear cell carcinoma of the ovary (CCC) and show that CD133 interacts with plakoglobin (also known as γ-catenin), a desmosomal linker protein. We further demonstrate that knockdown of CD133 by RNA interference (RNAi) results in the downregulation of desmoglein-2, a desmosomal cadherin, and abrogates cell-cell adhesion and tumorigenicity of CCC stem cells. We speculate that CD133 may be a promising target for cancer chemotherapy.

Share this book

Add to My Shelf

Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

AC133 Antigen

/ Animals

/ Antigens, CD - metabolism

/ Biology

/ Biomarkers, Tumor - metabolism

/ Caco-2 Cells

/ Cadherins