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High Expression of Neuro-Oncological Ventral Antigen 1 Correlates with Poor Prognosis in Hepatocellular Carcinoma
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High Expression of Neuro-Oncological Ventral Antigen 1 Correlates with Poor Prognosis in Hepatocellular Carcinoma
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Journal Article
High Expression of Neuro-Oncological Ventral Antigen 1 Correlates with Poor Prognosis in Hepatocellular Carcinoma
2014
Overview
Neuro-oncological ventral antigen 1 (Nova1) is a neuron-specific RNA-binding protein in human paraneoplastic opsoclonus-myoclonus ataxia accompanying with malignant tumors, but its role in hepatocellular carcinoma (HCC) remains elusive. In this study, we found that overexpressed intratumoral Nova1 was associated with poor survival rate and increased recurrence rate of HCC, especially early recurrence, and was an independent prognostic factor for overall survival rate and tumor recurrence. HCC cell lines over-expressing Nova1 exhibited greater potentials in cell proliferation, invasion and migration, while knockdown of Nova1 had the opposite effects. All these findings indicate that Nova1 may act as a prognostic marker for poor outcome and high recurrence in HCC.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Ataxia
/ Biology
/ Biomarkers, Tumor - genetics
/ Biomarkers, Tumor - metabolism
/ Carcinoma, Hepatocellular - genetics
/ Carcinoma, Hepatocellular - mortality
/ Carcinoma, Hepatocellular - pathology
/ Carcinoma, Hepatocellular - surgery
/ Female
/ Humans
/ Liver Neoplasms - metabolism
/ Medicine
/ Neoplasm Recurrence, Local - genetics
/ Neoplasm Recurrence, Local - mortality
/ Neoplasm Recurrence, Local - pathology
/ Neoplasm Recurrence, Local - surgery
/ RNA
/ RNA, Small Interfering - genetics
/ RNA, Small Interfering - metabolism
/ RNA-Binding Proteins - antagonists & inhibitors
/ RNA-Binding Proteins - genetics
/ RNA-Binding Proteins - metabolism
/ Rodents
/ Survival
/ Tumors
