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De-novo malignancies after kidney transplantation: A long-term observational study
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De-novo malignancies after kidney transplantation: A long-term observational study
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Journal Article
De-novo malignancies after kidney transplantation: A long-term observational study
2020
Overview
De-novo malignancies after kidney transplantation represent one major cause for mortality after transplantation. However, most of the studies are limited due to small sample size, short follow-up or lack of information about cancer specific mortality.
This long-term retrospective analysis included all adult patients with complete follow-up that underwent kidney transplantation between 1995 and 2016 at our centre. All patients with diagnosis of malignancy excluding non-melanoma skin cancer (NMSC) were identified and a matched control group was assigned to the kidney transplant recipients with post-transplant malignancies.
1417 patients matched the inclusion criteria. 179 malignancies posttransplant were diagnosed in 154 patients (n = 21 with two, n = 2 patients with three different malignancies). Mean age at cancer diagnosis was 60.3±13.3 years. Overall incidence of de-novo malignancies except NMSC was 1% per year posttransplant. Renal cell carcinoma was the most common entity (n = 49, incidence 4.20 per 1000 patient years; cancer specific mortality 12%), followed by cancer of the gastro-intestinal tract (n = 30, 2.57; 50%), urinary system (n = 24, 2.06; 13%), respiratory system (n = 18, 1.54; 89%), female reproductive system (n = 15, 1.29; 13%), posttransplant lymphoproliferative disorders and haematological tumours (n = 14, 1.20; 21%), cancers of unknown primary (n = 7, 0.60 100%) and others (n = 22, 1.89; 27%). Male sex, re-transplantation and time on dialysis were associated with de-novo malignancies after transplantation.
De-novo malignancies continue to be a serious problem after kidney transplantation. To improve long-term outcome after Kidney transplantation, prevention and cancer screening should be more tailored and intensified.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
/ Age
/ Aged
/ Cancer
/ Carcinoma, Renal Cell - diagnosis
/ Carcinoma, Renal Cell - epidemiology
/ Carcinoma, Renal Cell - etiology
/ Carcinoma, Renal Cell - pathology
/ Complications and side effects
/ Dialysis
/ Female
/ Humans
/ Immunoproliferative diseases
/ Immunosuppressive Agents - adverse effects
/ Immunosuppressive Agents - therapeutic use
/ Kidney Transplantation - adverse effects
/ Kidneys
/ Liver Transplantation - adverse effects
/ Lymphoproliferative Disorders - diagnosis
/ Lymphoproliferative Disorders - epidemiology
/ Lymphoproliferative Disorders - etiology
/ Lymphoproliferative Disorders - pathology
/ Male
/ Medicine and Health Sciences
/ Melanoma
/ Patients
/ Posttransplant lymphoproliferative disorders
/ Prostate
/ Tumors
