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Methylene Blue Protects Astrocytes against Glucose Oxygen Deprivation by Improving Cellular Respiration

by Ryou, Myoung-Gwi , Yuan, Fang , Yang, Shao-Hua , Gryczynski, Zygmunt , Liu, Ran , Rich, Ryan M. , Roy Choudhury, Gourav , Winters, Ali

in Adenosine Triphosphate - biosynthesis / Aging / Animals / Apoptosis / Astrocytes / Astrocytes - drug effects / Astrocytes - physiology / Bioenergetics / Brain / Brain injuries / Brain injury / Brain research / Cell death / Cell Hypoxia / Cell Respiration - drug effects / Cell Survival / Cells, Cultured / Cellular manufacture / Cytoprotection / Deprivation / Drug Evaluation, Preclinical / Energy / Glucose / Glucose - metabolism / Glycogen - biosynthesis / Head injuries / Hexokinase - metabolism / Immunology / Ischemia / Metabolism / Methylene blue / Methylene Blue - pharmacology / Mice, Inbred C57BL / Neurodegeneration / Neurological disorders / Neurons / Neuroprotective Agents - pharmacology / Neurosciences / Neurosurgery / Oxygen / Oxygen - metabolism / Oxygen Consumption / Pharmacology / Physiological aspects / Physiology / Respiration / Science / Stroke

2015

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Methylene Blue Protects Astrocytes against Glucose Oxygen Deprivation by Improving Cellular Respiration

by Ryou, Myoung-Gwi , Yuan, Fang , Yang, Shao-Hua , Gryczynski, Zygmunt , Liu, Ran , Rich, Ryan M. , Roy Choudhury, Gourav , Winters, Ali

2015

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Methylene Blue Protects Astrocytes against Glucose Oxygen Deprivation by Improving Cellular Respiration

by Ryou, Myoung-Gwi , Yuan, Fang , Yang, Shao-Hua , Gryczynski, Zygmunt , Liu, Ran , Rich, Ryan M. , Roy Choudhury, Gourav , Winters, Ali

2015

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Journal Article

Methylene Blue Protects Astrocytes against Glucose Oxygen Deprivation by Improving Cellular Respiration

Ryou, Myoung-Gwi,

Yuan, Fang,

Yang, Shao-Hua,

Gryczynski, Zygmunt,

Liu, Ran,

Rich, Ryan M.,

Roy Choudhury, Gourav,

Winters, Ali

2015

Overview

Astrocytes outnumber neurons and serve many metabolic and trophic functions in the mammalian brain. Preserving astrocytes is critical for normal brain function as well as for protecting the brain against various insults. Our previous studies have indicated that methylene blue (MB) functions as an alternative electron carrier and enhances brain metabolism. In addition, MB has been shown to be protective against neurodegeneration and brain injury. In the current study, we investigated the protective role of MB in astrocytes. Cell viability assays showed that MB treatment significantly protected primary astrocytes from oxygen-glucose deprivation (OGD) & reoxygenation induced cell death. We also studied the effect of MB on cellular oxygen and glucose metabolism in primary astrocytes following OGD-reoxygenation injury. MB treatment significantly increased cellular oxygen consumption, glucose uptake and ATP production in primary astrocytes. In conclusion our study demonstrated that MB protects astrocytes against OGD-reoxygenation injury by improving astrocyte cellular respiration.

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

Adenosine Triphosphate - biosynthesis

/ Aging

/ Animals

/ Apoptosis

/ Astrocytes

/ Astrocytes - drug effects

/ Astrocytes - physiology