Journal Article

Risk of cutaneous squamous cell carcinoma due to occupational exposure to solar ultraviolet radiation: Protocol for a systematic review and meta-analysis

Peters, Cheryl E., Gobba, Fabriziomaria, Tenkate, Thomas, van der Molen, Henk F., Rocholl, Marc, John, Swen Malte, Wittlich, Marc, Ádam, Balázs, Kezic, Sanja, Paulo, Marília Silva, Symanzik, Cara, Loney, Tom, Modenese, Alberto

2023

Overview

Solar ultraviolet radiation (UVR) is the most significant occupational carcinogenic exposure in terms of the number of workers exposed (i.e., outdoor workers). Consequently, solar UVR-induced skin cancers are among the most common forms of occupational malignancies that are potentially expected globally. This systematic review is registered in PROSPERO (CRD42021295221) and aims to assess the risk of cutaneous squamous cell carcinoma (cSCC) associated to occupational solar UVR exposure. Systematic searches will be performed in three electronic literature databases (PubMed/Medline, EMBASE, and Scopus). Further references will be retrieved by a manual search (e.g., in grey literature databases, internet search engines, and organizational websites). We will include cohort studies and case-control studies. Risk of Bias assessment will be conducted separately for case-control and cohort studies. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) will be used for the certainty of assessment. In case quantitative pooling is not feasible, a narrative synthesis of results will be performed.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Auroral kilometric radiation / Cancer / Carcinogens / Carcinoma, Squamous Cell / Diagnosis / Employment / Exposure / Health aspects / Humans / Internet/Web search services / Malignancy / Medical diagnosis / Medicine and Health Sciences / Melanoma / Meta-analysis / Meta-Analysis as Topic / Neoplasms, Radiation-Induced / Occupational exposure / Occupational health / Online databases / Outdoors / Physical Sciences / Quality / Research and Analysis Methods / Risk assessment / Risk factors / Risk management / Search engines / Skin / Skin cancer / Skin Neoplasms / Solar radiation / Solar ultraviolet radiation / Squamous cell carcinoma / Study Protocol / Sunburn & sun tanning / Systematic review / Systematic Reviews as Topic / Ultraviolet radiation / Ultraviolet Rays / Websites / Workers