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Microtubule-associated protein 1B is implicated in stem cell commitment and nervous system regeneration in planarians

by Iacopetti, Paola , Guidi, Patrizia , Ippolito, Chiara , Ghezzani, Claudio , Linsalata, Stefania , Gambino, Gaetana , Rossi, Leonardo , Salvetti, Alessandra

in Animals / Anomalies / Antibodies / Apoptosis / Biology and life sciences / Body parts / Cell cycle / Control systems / Cytoskeleton / Experiments / Flow cytometry / Ganglia / Glycerol / Health aspects / Hybridization / Independent sample / Medicine and Health Sciences / Microscopy / Microtubule-associated protein 1 / Nervous System / Neuropeptides / Neurotransmitter release / Neurotransmitters / Planarians - genetics / Platyhelminthes / Proteins / Regeneration / Stem cell transplantation / Stem cells / Stem Cells - metabolism / Turbellaria / X-rays

2022

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Microtubule-associated protein 1B is implicated in stem cell commitment and nervous system regeneration in planarians

by Iacopetti, Paola , Guidi, Patrizia , Ippolito, Chiara , Ghezzani, Claudio , Linsalata, Stefania , Gambino, Gaetana , Rossi, Leonardo , Salvetti, Alessandra

2022

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Microtubule-associated protein 1B is implicated in stem cell commitment and nervous system regeneration in planarians

by Iacopetti, Paola , Guidi, Patrizia , Ippolito, Chiara , Ghezzani, Claudio , Linsalata, Stefania , Gambino, Gaetana , Rossi, Leonardo , Salvetti, Alessandra

2022

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Journal Article

Microtubule-associated protein 1B is implicated in stem cell commitment and nervous system regeneration in planarians

Iacopetti, Paola,

Guidi, Patrizia,

Ippolito, Chiara,

Ghezzani, Claudio,

Linsalata, Stefania,

Gambino, Gaetana,

Rossi, Leonardo,

Salvetti, Alessandra

2022

Overview

Microtubule-associated 1B (MAP1B) proteins are expressed at the nervous system level where they control cytoskeleton activity and regulate neurotransmitter release. Here, we report about the identification of a planarian MAP1B factor ( DjMap1B ) that is enriched in cephalic ganglia and longitudinal nerve cords but not in neoblasts, the plentiful population of adult stem cells present in planarians, thanks to which these animals can continuously cell turnover and regenerate any lost body parts. DjMap1B knockdown induces morphological anomalies in the nervous system and affects neoblast commitment. Our data put forward a correlation between a MAP1B factor and stem cells and suggest a function of the nervous system in non-cell autonomous control of planarian stem cells.

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Publisher

Public Library of Science,Public Library of Science (PLoS)

Subject

/ Biology and life sciences

/ Body parts

/ Cell cycle